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Titolo:
Cytokine-associated emotional and cognitive disturbances in humans
Autore:
Reichenberg, A; Yirmiya, R; Schuld, A; Kraus, T; Haack, M; Morag, A; Pollmacher, T;
Indirizzi:
Hebrew Univ Jerusalem, Dept Psychol, Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel Dept Psychol, Jerusalem, Israel Max Planck Inst Psychiat, D-8000 Munich, Germany Max Planck Inst PsychiatMunich Germany D-8000 t, D-8000 Munich, Germany Hadassah Hebrew Univ, Clin Virol Unit, Med Ctr, Jerusalem, Israel HadassahHebrew Univ Jerusalem Israel Unit, Med Ctr, Jerusalem, Israel
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 5, volume: 58, anno: 2001,
pagine: 445 - 452
SICI:
0003-990X(200105)58:5<445:CEACDI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MEMORY CONSOLIDATION; DECLARATIVE MEMORY; INTERFERON-ALPHA; HUMAN SLEEP; ENDOTOXIN; DEPRESSION; THERAPY; PERFORMANCE; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Yirmiya, R Hebrew Univ Jerusalem, Dept Psychol, Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel ol, Jerusalem, Israel
Citazione:
A. Reichenberg et al., "Cytokine-associated emotional and cognitive disturbances in humans", ARCH G PSYC, 58(5), 2001, pp. 445-452

Abstract

Background: Infectious, autoimmune, and neurodegenerative diseases are associated with profound psychological disturbances. Studies in animals clearly demonstrate that cytokines mediate illness-associated behavioral changes. However, the mechanisms underlying the respective psychological alterations in humans have not been established yet. Therefore, we investigated the effects of low-dose endotoxemia, a well-established and safe model of host-defense activation, on emotional, cognitive, immunological, and Endocrine parameters. Methods: In a double-blind, crossover study, 20 healthy male volunteers completed psychological questionnaires and neuropsychological tests 1, 3, and9 hours after intravenous injection of Salmonella abortus equi endotoxin (0.8 ng/kg) or saline in 2 experimental sessions. Blood samples were collected hourly, and rectal temperature and heart rate were monitored continuously. Results; Endotoxin had no effects on physical sickness symptoms, blood. pressure, or heart rate. Endotoxin caused a mild increase in rectal temperature (0.5 degreesC), and increased the circulating levels of tumor necrosis factor or (TNF-alpha), soluble TNF receptors, interleukin (IL)-6, IL-1 receptor antagonist, and cortisol. After endotoxin administration, the subjects showed a transient significant increase in the levels of anxiety (effect size [ES] = 0.55) and depressed mood (ES = 0.66). Verbal and nonverbal memoryfunctions were significantly decreased (ES = 0.55 to 0.64). Significant positive correlations were found between cytokine secretion and endotoxin-induced anxiety (r = 0.49 to r = 0.60), depressed mood (r = 0.40 to r = 0.75),and decreases in memory performance (r = 0.46 to r = 0.68). Conclusions: In humans, a mild stimulation of the primary host defense hasnegative effects on emotional and memory functions, which are probably caused by cytokine release. Hence, cytokines represent a novel target for neuropsychopharmacological research.

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Documento generato il 21/01/20 alle ore 01:16:22