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Titolo:
Human trophoblast invasion and spiral artery transformation - The role of PECAM-1 in normal pregnancy, preeclampsia, and fetal growth restriction
Autore:
Lyall, F; Bulmer, JN; Duffie, E; Cousins, F; Theriault, A; Robson, SC;
Indirizzi:
Duncan Guthrie Inst Med Genet, Maternal & Fetal Med Sect, Glasgow G3 8SJ, Lanark, Scotland Duncan Guthrie Inst Med Genet Glasgow Lanark Scotland G3 8SJ rk, Scotland Royal Victoria Infirm, Dept Pathol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England Royal Victoria Infirm Newcastle Upon Tyne Tyne & Wear England NE1 4LP and Royal Victoria Infirm, Dept Obstet & Gynaecol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England Royal Victoria Infirm Newcastle Upon Tyne Tyne & Wear England NE1 4LP and
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 5, volume: 158, anno: 2001,
pagine: 1713 - 1721
SICI:
0002-9440(200105)158:5<1713:HTIASA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE-1; HUMAN PLACENTAL BED; HUMAN CYTOTROPHOBLASTS; INTERSTITIAL TROPHOBLAST; ENDOVASCULAR INVASION; MORPHOLOGICAL-CHANGES; PULSATILITY INDEX; PRE-ECLAMPSIA; BIRTH-WEIGHT; BLOOD-FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Lyall, F Duncan Guthrie Inst Med Genet, Maternal & Fetal Med Sect, Yorkhill, Glasgow G3 8SJ, Lanark, Scotland Duncan Guthrie Inst Med Genet Yorkhill Glasgow Lanark Scotland G3 8SJ
Citazione:
F. Lyall et al., "Human trophoblast invasion and spiral artery transformation - The role of PECAM-1 in normal pregnancy, preeclampsia, and fetal growth restriction", AM J PATH, 158(5), 2001, pp. 1713-1721

Abstract

During early human pregnancy extravillous cytotrophoblasts invade the uterus and spiral arteries transforming them into large vessels of low resistance, Failure of trophoblast invasion and spiral artery transformation occursin preeclampsia and fetal growth restriction (FGR); these processes are not well understood. Recent studies have suggested that cytotrophoblasts thatinvade spiral arteries mimic the endothelial cells they replace and express PECAM-1. It was also reported that in preeclampsia, cytotrophoblasts failto express PECAM-1 and that failure to express endothelial cell adhesion molecules may account for failed trophoblast invasion. Despite the possible importance of adhesion molecules in trophoblast invasion, no study has systematically investigated the expression of PECAM-1 in the placental bed throughout the period of invasion, particularly in the myometrial segments where the key failure occurs. There are no studies on PECAM-1 expression in theplacental bed in FGR, We have examined the expression of PECAM-1 in placental bed biopsies and placentas from 8 to 19 weeks Of gestation and in the placenta and placental bed in the third trimester in cases of preeclampsia, FGR, and control pregnancies. PECAM-1 was expressed on endothelium of vessels in the placenta and placental bed but not by villous or extravillous trophoblasts in normal or pathological samples. These findings do not support a role for PECAM-1 in normal invasion or in the pathophysiology of preeclampsia or FGR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 19:23:03