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Titolo:
Effect of folic acid treatment on endothelium-dependent vasodilation and nitric oxide-derived end products in hyperhomocysteinemic subjects
Autore:
Holven, KB; Holm, T; Aukrust, P; Christensen, B; Kjekshus, J; Andreassen, AK; Gullestad, L; Hagve, TA; Svilaas, A; Ose, L; Nenseter, MS;
Indirizzi:
Univ Hosp, Lipid Clin, Rikshosp, N-0027 Oslo, Norway Univ Hosp Oslo Norway N-0027 , Lipid Clin, Rikshosp, N-0027 Oslo, Norway Ulleval Univ Hosp, Dept Med Genet, Oslo, Norway Ulleval Univ Hosp Oslo Norway l Univ Hosp, Dept Med Genet, Oslo, Norway Univ Hosp, Inst Clin Biochem, Rikshosp, Oslo, Norway Univ Hosp Oslo Norway v Hosp, Inst Clin Biochem, Rikshosp, Oslo, Norway Univ Hosp, Inst Internal Med, Rikshosp, Div Heart & Lung Dis, Oslo, NorwayUniv Hosp Oslo Norway Med, Rikshosp, Div Heart & Lung Dis, Oslo, Norway Univ Hosp, Dept Med, Rikshosp, Sect Clin Immunol & Infect Dis, Oslo, Norway Univ Hosp Oslo Norway osp, Sect Clin Immunol & Infect Dis, Oslo, Norway Univ Hosp, MSD Cardiovasc Res Ctr, Rikshosp, Oslo, Norway Univ Hosp OsloNorway p, MSD Cardiovasc Res Ctr, Rikshosp, Oslo, Norway Univ Hosp, Dept Cardiol, Rikshosp, Oslo, Norway Univ Hosp Oslo NorwayUniv Hosp, Dept Cardiol, Rikshosp, Oslo, Norway
Titolo Testata:
AMERICAN JOURNAL OF MEDICINE
fascicolo: 7, volume: 110, anno: 2001,
pagine: 536 - 542
SICI:
0002-9343(200105)110:7<536:EOFATO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA HOMOCYSTEINE; RISK FACTOR; DYSFUNCTION; HYPERHOMOCYST(E)INEMIA; CELLS; HUMANS; HYPERCHOLESTEROLEMIA; DIMETHYLARGININE; MECHANISMS; NITRATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Nenseter, MS Univ Hosp, Lipid Clin, Rikshosp, N-0027 Oslo, Norway Univ Hosp Oslo Norway N-0027 Rikshosp, N-0027 Oslo, Norway
Citazione:
K.B. Holven et al., "Effect of folic acid treatment on endothelium-dependent vasodilation and nitric oxide-derived end products in hyperhomocysteinemic subjects", AM J MED, 110(7), 2001, pp. 536-542

Abstract

PURPOSE: An elevated plasma homocysteine concentration is an independent risk factor for cardiovascular diseases, In this study, we tested the hypothesis that hyperhomocyteinemia induces endothelial dysfunction mediated, at least in part, through nitric oxide-dependent mechanisms and that folic acid supplementation improves endothelial function in hyperhomocysteinemic subjects. SUBJECTS AND METHODS: Endothelial function was evaluated in healthy controls and hyperhomocysteinemic subjects by measuring plasma levels of the nitric oxide-derived end products nitrite and nitrate and by assessing vasodilatory responses in the skin microcirculation and forearm vasculature. in thesubjects with hyperhomocysteinemia, these measurements were repeated after6 weeks and 12 months of folic acid supplementation. RESULTS: Compared with healthy controls, hyperhomocysteinemic subjects hadsignificantly lower median plasma levels of nitric oxide-derived end products (12.1 muM [range 4.4 to 41.8] versus 24.6 muM [13.6 to 53.2]; P <0.001), a significantly lower endothelium-dependent vasodilatory response to acetylcholine (P <0.01), hyperemic response in the microcirculation (P <0.01), and total forearm blood flow during reactive hyperemia (P = 0.01). There was no significant difference in the endothelium-independent response, Folic acid treatment for 12 months increased the plasma level of nitric oxide-derived end products by 121% (95% confidence interval [CI], 72% to 170%), the vasodilatory response to acetylcholine by 124% (95% CI, 36% to 212%), and the ischemia-mediated hyperemic responses in the microcirculation by 60% (95% CI, 25% to 96%) and in the forearm vasculature by 47% (95% CI, 21% to 73%)CONCLUSIONS: Homocysteine appears to induce its atherogenic effect, at least in part, by depressing endothelial function, possibly through nitric oxide-dependent mechanisms. This effect call be reversed by folic acid supplementation. (C) 2001 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:46:12