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Titolo:
Relationship between Taq1 A dopamine D2 receptor (DRD2) polymorphism and prolactin response to bromperidol
Autore:
Mihara, K; Suzuki, A; Kondo, T; Yasui-Furukori, N; Ono, S; Otani, K; Kaneko, S; Inoue, Y;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Yamagata Univ, Sch Med, Dept Neuropsychiat, Yamagata 99023, Japan YamagataUniv Yamagata Japan 99023 Neuropsychiat, Yamagata 99023, Japan Welfide Corp, Div Pharmaceut Res, Fukuoka, Japan Welfide Corp Fukuoka Japan ide Corp, Div Pharmaceut Res, Fukuoka, Japan
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 3, volume: 105, anno: 2001,
pagine: 271 - 274
SICI:
0148-7299(20010408)105:3<271:RBTADD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC-PATIENTS; A1 ALLELE; HEALTHY-VOLUNTEERS; GENE; BINDING; BRAIN; PERFORMANCE; ASSOCIATION; NEMONAPRIDE; CHILDREN;
Keywords:
prolactin response; dopamine D2 receptor; Taq1 A polymorphism; bromperidol; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Mihara, K Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 mori 0368562, Japan
Citazione:
K. Mihara et al., "Relationship between Taq1 A dopamine D2 receptor (DRD2) polymorphism and prolactin response to bromperidol", AM J MED G, 105(3), 2001, pp. 271-274

Abstract

The dopamine D2 receptor (DRD2) gene has a Taq1 A restriction fragment length polymorphism yielding two alleles, A1 and A2. We have previously shown that female patients with the Al allele show greater prolactin response to nemonapride, a selective antagonist, for D2-like dopamine receptors, in schizophrenic patients. In the present study, the relationship between this polymorphism and prolactin response to bromperidol was investigated in 32 untreated schizophrenic inpatients (16 males, 16 females). The daily dose of bromperidol was fixed at 6 (n = 10), 12 (n = 13), or 18 mg (n = 9) during a a-week treatment period. Taq1 A genotypes were determined by PCR method. Plasma prolactin concentration was measured by radioimmunoassay. Plasma concentration of bromperidol was measured by HPLC method. The subjects were divided into four subgroups by gender and the genotypes, i.e., 10 males and 11 females with the A1 allele, 6 males and 5 females with no Al allele, The females with the A1 allele had the highest Delta prolactin (the change from the pretreatment concentration)/bromperidol concentration ratio among the other groups (P < 0.05). The present study; thus suggests that female patients with the Al allele show greater prolactin response to bromperidol, wr ho may have a high risk for adverse effects associated with neuroleptic-induced hyperprolactinemia. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 19:31:57