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Titolo:
Analysis of epistasis in linked regions in the Irish Study of High-DensitySchizophrenia Families
Autore:
Sullivan, PF; ONeill, FA; Walsh, D; Ma, YL; Kendler, KS; Straub, RE;
Indirizzi:
Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 3, volume: 105, anno: 2001,
pagine: 266 - 270
SICI:
0148-7299(20010408)105:3<266:AOEILR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-LINKAGE MAP; ROSCOMMON FAMILY; VULNERABILITY LOCUS; QUANTITATIVE TRAITS; COMPLEX TRAITS; SUSCEPTIBILITY; RELATIVES; CHROMOSOME-2; DISORDERS; GENOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Sullivan, PF Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, POB 980126, Richmond, VA 23298 USA Virginia Commonwealth Univ POB 980126 Richmond VA USA 23298 A
Citazione:
P.F. Sullivan et al., "Analysis of epistasis in linked regions in the Irish Study of High-DensitySchizophrenia Families", AM J MED G, 105(3), 2001, pp. 266-270

Abstract

Epistasis may be important in the etiology of schizophrenia. Analysis of epistasis has been important in the positional cloning of a gene involved inthe etiology of type II diabetes mellitus. We investigated the importance of epistasis among sis linked regions in 268 multiplex pedigrees in the Irish Study of High-Density Schizophrenia Families (ISHDSF) by computing pairwise correlations between nonparametric linkage scores for narrow, intermediate, and bread diagnostic definitions. The linked regions mere on chromosomes 2, 4, 5, 6, 8, and 10. No correlation reached our a priori level of statistical significance. Using this statistical approach, we did not find evidence of important epistatic effects among these sis regions in the ISHDSF. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 02/07/20 alle ore 19:22:17