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Titolo:
Genetic association analysis of behavioral inhibition using candidate locifrom mouse models
Autore:
Smoller, JW; Rosenbaum, JF; Biederman, J; Susswein, LS; Kennedy, J; Kagan, J; Snidman, N; Laird, N; Tsuang, MT; Faraone, SV; Schwarz, A; Slaugenhaupt, SA;
Indirizzi:
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Psychiat, Boston, MA 02114 USA Harvard Univ, Sch Med, Inst Human Genet, Boston, MA USA Harvard Univ Boston MA USA iv, Sch Med, Inst Human Genet, Boston, MA USA Massachusetts Gen Hosp, Mol Neurogenet Unit, Boston, MA USA Massachusetts Gen Hosp Boston MA USA Mol Neurogenet Unit, Boston, MA USA Harvard Univ, Dept Psychol & Social Relat, Cambridge, MA 02138 USA HarvardUniv Cambridge MA USA 02138 Social Relat, Cambridge, MA 02138 USA Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hlth, Dept Biostat, Boston, MA 02115 USA Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA Massachusetts Mental Hlth Ctr Boston MA USA 02115 r, Boston, MA 02115 USA Brockton W Roxbury Vet Affairs Med Ctr, Brockton, MA USA Brockton W Roxbury Vet Affairs Med Ctr Brockton MA USA Brockton, MA USA Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Epidemiol & Genet, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 3, volume: 105, anno: 2001,
pagine: 226 - 235
SICI:
0148-7299(20010408)105:3<226:GAAOBI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILY-BASED TESTS; DINUCLEOTIDE REPEAT POLYMORPHISM; GLUTAMIC-ACID DECARBOXYLASE; ADENOSINE A(2A) RECEPTOR; QUANTITATIVE TRAIT LOCI; PANIC DISORDER; SOCIAL PHOBIA; LINKAGE DISEQUILIBRIUM; ANXIETY DISORDERS; MAJOR DEPRESSION;
Keywords:
genetic; behavioral inhibition; anxiety; candidate genes; mouse; association study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Smoller, JW Massachusetts Gen Hosp, Dept Psychiat, 15 Parkman St,WACC-815,Boston, MA 02114 USA Massachusetts Gen Hosp 15 Parkman St,WACC-815 Boston MA USA 02114
Citazione:
J.W. Smoller et al., "Genetic association analysis of behavioral inhibition using candidate locifrom mouse models", AM J MED G, 105(3), 2001, pp. 226-235

Abstract

Genes influence the development of anxiety disorders, but the specific loci involved are not known. Genetic association studies of anxiety disorders are complicated by the complexity of the phenotypes and the difficulty in identifying appropriate candidate loci, S Ve have begun to examine the genetics of behavioral inhibition to the unfamiliar (BI), a heritable temperamental predisposition that is a developmental and familial risk factor for panic and phobic disorders. Specific loci associated with homologous phenotypes in mouse models provide compelling candidate genes for human BI. We conducted family-based association analyses of BI using four genes derived from genetic studies of mouse models with features of behavioral inhibition. Thesample included families of 72 children classified as inhibited by structured behavioral assessments. We observed modest evidence of association (P=0.05) between BI and the glutamic acid decarboxylase gene (65 kDA isoform), which encodes an enzyme involved in GABA synthesis. No significant evidenceof association was observed for the genes encoding the adenosine A(1A) receptor, the adenosine A(2A) receptor, or preproenkephalin, This study illustrates the potential utility of using candidate genes derived from mouse models to dissect the genetic basis of BI, a possible intermediate phenotype for panic and phobic disorders, (C) 2001 Wiley-Liss, Inc.

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Documento generato il 31/03/20 alle ore 04:38:43