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Titolo:
Use of positron emission tomography in analysing receptor function in vivo
Autore:
Hartvig, P; Bergstrom, M; Langstrom, B;
Indirizzi:
Univ Uppsala Hosp, PET Ctr, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 ET Ctr, S-75185 Uppsala, Sweden
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 1-3, volume: 120, anno: 2001,
pagine: 243 - 251
SICI:
0378-4274(20010331)120:1-3<243:UOPETI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-11 RACLOPRIDE BINDING; PARKINSONS-DISEASE; SYNAPTIC DOPAMINE; DRUG DEVELOPMENT; PET MEASUREMENTS; RHESUS-MONKEY; BRAIN; SCHIZOPHRENIA; EXPOSURE; TOLUENE;
Keywords:
positron emission tomography; dopamine; acetylcholine; serotonin; toxicological mechanisms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Hartvig, P Univ Uppsala Hosp, PET Ctr, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 5185 Uppsala, Sweden
Citazione:
P. Hartvig et al., "Use of positron emission tomography in analysing receptor function in vivo", TOX LETT, 120(1-3), 2001, pp. 243-251

Abstract

The non-invasive radiotracer technique positron emission tomography (PET) may provide valuable information in the toxicokinetic-toxicodynamic evaluation of endogenous or toxic environmental compounds. Assessment of mechanismof action of toxins is often difficult to validate. In this respect. PET may offer advantages since it can quantify not only the distribution and kinetics of the radiolabelled toxin in the body, but also the altered rates ofphysiological or biochemical processes induced by the toxin. II is even possible to validate the body distribution and tissue accumulation of the toxic compound in primates, since linear kinetics can be assumed after administration of the radiolabelled compound in minute amounts without any toxic or physiological effects. Quantitative estimates can be derived with accuracy and high precision. Using a multi-tracer protocol, it is often possible to illuminate both the kinetics and the dynamics of a toxic compound. Long-term effects of different toxins on dopamine receptor function have been evaluated with PET as well as the influence of Parkinson disease medication onpre- and postsynaptic dopaminergic receptor function over the course of the disease. In conclusion, PET may provide very informative insight into complex receptor interactions of both toxic compounds and drugs under development. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:03:59