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Titolo:
The use of toxicodynamics in risk assessment
Autore:
Heinrich-Hirsch, B; Madle, S; Oberemm, A; Gundert-Remy, U;
Indirizzi:
Fed Inst Hlth Protect Consumers & Vet Med, BgVV, Dept Assessment Chem, D-14195 Berlin, Germany Fed Inst Hlth Protect Consumers & Vet Med Berlin Germany D-14195 Germany
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 1-3, volume: 120, anno: 2001,
pagine: 131 - 141
SICI:
0378-4274(20010331)120:1-3<131:TUOTIR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPRODUCTIVE ORGAN DEVELOPMENT; BISPHENOL-A; CANCER RISK; IN-VIVO; CHROMOSOMAL-ABERRATIONS; HAZARDOUS SUBSTANCES; PROTEOME ANALYSIS; HEALTH RISK; EXPOSURE; LYMPHOCYTES;
Keywords:
risk assessment; toxicodynamics; endpoints;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Gundert-Remy, U Fed Inst Hlth Protect Consumers & Vet Med, BgVV, Dept Assessment Chem, Thielallee 88-92, D-14195 Berlin, Germany Fed Inst Hlth Protect Consumers & Vet Med Thielallee 88-92 Berlin Germany D-14195
Citazione:
B. Heinrich-Hirsch et al., "The use of toxicodynamics in risk assessment", TOX LETT, 120(1-3), 2001, pp. 131-141

Abstract

Risk assessment of xe(n)obiotics is a qualitative and quantitative assessment of toxic properties conventionally based on data resulting from in animals exposed to the substance The assessment of dose-effect relationship includes evaluation of exposure at the site of action. More recently, emphasisis put on understanding the relationship between exposure at the site of action and the resulting effect, i.e. toxicodynamic. In this respect, results from genotoxicity studies may be a measure for exposure and at the same time of an effect. Results of toxicodynamic endpoints such as binding to receptors or release of hormones have been used when replacing default values for interspecies extrapolation. It may also be envisaged to use toxicodynamic endpoints in order to egt an estimate of intraspecies variability. It was demonstrated that this approach may be helpful only if the relationship between the toxicodynamic endpoint and the definite endpoint is known by using the example of bisphenol A. Whereas there are clear effects of bisphenolA in in vitro and ex vivo studies, the classical two generation study has not been able to detect an effect on reproduction and/or fertility. Lookingin the future development of toxicodynamic endpoints, gene profiling and the analysis of proteins ('proteomics') may be helpful tools employed in screening and being related to the mode of action are explored for their suitability in terms of toxicodynamic endpoints. (C) 2001 Elsevier Science Ireland Ltd. All lights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:00:34