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Titolo:
Comparing the clastogenic potential of atrazine with caffeine using Chinese hamster ovary (CHO) cells
Autore:
Rayburn, AL; Bouma, J; Northcott, CA;
Indirizzi:
Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 is, Dept Crop Sci, Urbana, IL 61801 USA Univ Idaho, Dept Biol Sci, Moscow, ID 83844 USA Univ Idaho Moscow ID USA 83844 Idaho, Dept Biol Sci, Moscow, ID 83844 USA Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 xicol, E Lansing, MI 48824 USA
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 1, volume: 121, anno: 2001,
pagine: 69 - 78
SICI:
0378-4274(20010408)121:1<69:CTCPOA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GEL-ELECTROPHORESIS; HUMAN-LYMPHOCYTES; WATER-SUPPLIES; FLOW-CYTOMETRY; DNA-DAMAGE; HERBICIDE; GENOTOXICITY; MUTATION; ASSAYS;
Keywords:
flow cytometery; chromosomes; flow karyotype; genotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Rayburn, AL Univ Illinois, Dept Crop Sci, 320 ERML, Urbana, IL 61801 USA Univ Illinois 320 ERML Urbana IL USA 61801 rbana, IL 61801 USA
Citazione:
A.L. Rayburn et al., "Comparing the clastogenic potential of atrazine with caffeine using Chinese hamster ovary (CHO) cells", TOX LETT, 121(1), 2001, pp. 69-78

Abstract

The agronomically important herbicide atrazine has been reported to cause damage to animal chromosomes at levels of atrazine found contaminating drinking water supplies. While documenting potential chromosome damage is important it is equally important to compare the damage with the potential consequences of compounds readily found in our food and water supply. In this study atrazine and caffeine. a ubiquitous food additive, were compared at equal levels and at real exposure levels for their ability to damage animals chromosomes in cell culture. Nuclei and chromosomes from treated and controlcells were analyzed by flow cytometry. At extremely low levels. atrazine was found to be a more potent clastogen. Caffeine had no effect on the chromosomes at the lower levels. Both chemicals were genotoxic at the potential exposure levels with caffeine being more disruptive than atrazine. Atrazineappears to be a more potent damaging agent than caffeine at similar levelsof exposure; however, the levels of caffeine one is exposed to during everyday life appears to be more damaging on the endpoints analyzed in this study than the levels of atrazine found contaminating water supplies. The advantages and limitations of whole cell clasotgenicity are also presented in light of these results. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 05:35:24