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Titolo:
Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: A new metabolic pathway?
Autore:
Nissbrandt, H; Bergquist, F; Jonason, J; Engberg, G;
Indirizzi:
Univ Gothenburg, Inst Physiol & Pharmacol, Dept Pharmacol, SE-40530 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden SE-40530 , SE-40530 Gothenburg, Sweden Karolinska Inst, Dept Physiol & Pharmacol, Div Pharmacol, Stockholm, Sweden Karolinska Inst Stockholm Sweden acol, Div Pharmacol, Stockholm, Sweden
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 40, anno: 2001,
pagine: 294 - 301
SICI:
0887-4476(20010615)40:4<294:IOCP2I>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENETHYL ISOTHIOCYANATE; DIALLYL SULFIDE; PHARMACOLOGICAL RESPONSIVENESS; LIPID-PEROXIDATION; LIVER; ENZYMES; RELEASE; BRAIN; DIETHYLDITHIOCARBAMATE; MICRODIALYSIS;
Keywords:
cytochrome P450 2E1; diallyl sulfide; diethyldithiocarbamate; dopamine; phenylethyl isothiocyanate; substantia nigra; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Nissbrandt, H Univ Gothenburg, Inst Physiol & Pharmacol, Dept Pharmacol, POB 431, SE-40530 Gothenburg, Sweden Univ Gothenburg POB 431 Gothenburg Sweden SE-40530 , Sweden
Citazione:
H. Nissbrandt et al., "Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: A new metabolic pathway?", SYNAPSE, 40(4), 2001, pp. 294-301

Abstract

We presented data previously on dopamine (DA) synthesis and catabolism in the rat substantia nigra (SN) suggesting that a substantial part of the synthesized DA in this brain part is metabolized by unknown nonclassical metabolic pathways. On the basis of that a relatively high density of cytochromeP450 2E1 (CYP 2E1) has been detected in rat SN the aim of the present study was to investigate the possibility that this enzyme is involved in the metabolism of DA. Systemic administration of either phenylethyl isothiocyanate (100 mg/kg ip), diethyldithiocarbamate (500 mg/kg, ip) or diallyl sulfide1200 mg/kg, sc or ip), three different inhibitors of cytochrome P450 2E1, induced an increase of the extracellular DA concentration in the SN, measured with microdialysis in awake rats, by 130%, 90%, and 35%, respectively. Atendency to increased concentrations of the classical DA metabolites in the dialysate from the SN was also observed in some experiments. In the striatum, no profound effects were induced by the drugs on the concentrations ofDA or its metabolites. The results show that CYP 2E1 activity affects dopaminergic neurotransmission in the SN, possibly by participating in DA metabolism. Other mechanisms, such as the influence on the DA transporter or therelease process cannot, however, be ruled out. Synapse 40:294301, 2001, (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:27:30