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Titolo:
Distribution of members of the PSD-95 family of MAGUK proteins at the synaptic region of inner and outer hair cells of the guinea pig cochlea
Autore:
Davies, C; Tingley, D; Kachar, B; Wenthold, RJ; Petralia, RS;
Indirizzi:
NIDCD, Neurochem Lab, NIH, Bethesda, MD 20892 USA NIDCD Bethesda MD USA 20892 D, Neurochem Lab, NIH, Bethesda, MD 20892 USA NIDCD, Sect Struct Cell Biol, NIH, Bethesda, MD USA NIDCD Bethesda MD USA IDCD, Sect Struct Cell Biol, NIH, Bethesda, MD USA
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 40, anno: 2001,
pagine: 258 - 268
SICI:
0887-4476(20010615)40:4<258:DOMOTP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE-RECEPTOR SUBUNIT; TUMOR-SUPPRESSOR PROTEIN; EFFERENT NERVE-TERMINALS; NITRIC-OXIDE SYNTHASE; K+ CHANNEL; POSTSYNAPTIC DENSITY-93; CLUSTERING ACTIVITY; GUANYLATE KINASES; AMPA RECEPTORS; NMDA RECEPTORS;
Keywords:
PSD-93; SAP-97; SAP-102; synapse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Petralia, RS NIDCD, Neurochem Lab, NIH, Bldg 36,Room 5D08, Bethesda, MD 20892 USA NIDCD Bldg 36,Room 5D08 Bethesda MD USA 20892 a, MD 20892 USA
Citazione:
C. Davies et al., "Distribution of members of the PSD-95 family of MAGUK proteins at the synaptic region of inner and outer hair cells of the guinea pig cochlea", SYNAPSE, 40(4), 2001, pp. 258-268

Abstract

PDZ-domain containing proteins of the MAGUK (membrane-associated guanylatekinase) family target, anchor, and cluster receptors and channels to subcellular sites. Among the MAGUK proteins, the members of the PSD-95 family (MAGUKs: PSD-95, PSD-93, SAP-97, and SAP-102) target and anchor glutamate receptors to the synaptic terminals. Associations of glutamate receptors with MAGUKs have been described in the brain but not in the cochlea. In this study, RT-PCR, immunofluorescence microscopy, and immunoelectron microscopy were used to investigate the presence and distribution of MAGUK proteins in the organ of Corti. The presence of the mRNA for PSD-95, PSD-93, SAP-97, andSAP-102 in the organ of Corti was confirmed by RT-PCR, Immunocytochemistryusing a "pan-MAGUK" antibody, which recognizes all four MAGUK proteins, and selective antibodies against these proteins revealed that all four MAGUKsare present within the base of inner hair cells while all except SAP-97 are found within the base of the outer hair cells. In addition, PSD-93 and PSD-95 are found in postsynaptic afferent terminals on inner hair cells, while postsynaptic afferent terminals on outer hair cells have PSD-93. Synapse 40:258-268, 2001, (C) 2001 Wiley-Liss, Inc.dagger

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:15:41