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Titolo:
Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmannglia
Autore:
Lino, M; Goto, K; Kakegawa, W; Okado, H; Sudo, M; Ishiuchi, S; Miwa, A; Takayasu, Y; Saito, I; Tsuzuki, K; Ozawa, S;
Indirizzi:
Gunma Univ, Sch Med, Gunma 3718511, Japan Gunma Univ Gunma Japan 3718511Gunma Univ, Sch Med, Gunma 3718511, Japan Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Kawaguchi, Saitama 3320012, Japan Japan Sci & Technol Corp Kawaguchi Saitama Japan 3320012 a 3320012, Japan Univ Tokyo, Inst Med Sci, Tokyo 1080071, Japan Univ Tokyo Tokyo Japan 1080071 Tokyo, Inst Med Sci, Tokyo 1080071, Japan Tokyo Metropolitan Inst Neurosci, Inst Neurosci, Dept Neurobiol, Fuchu, Tokyo 1838526, Japan Tokyo Metropolitan Inst Neurosci Fuchu Tokyo Japan 1838526 1838526, Japan
Titolo Testata:
SCIENCE
fascicolo: 5518, volume: 292, anno: 2001,
pagine: 926 - 929
SICI:
0036-8075(20010504)292:5518<926:GITCAR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR PURKINJE-CELLS; GLUTAMATE RECEPTORS; KAINATE RECEPTORS; CHANNELS; DESENSITIZATION; TRANSPORTERS; PERMEABILITY; SUBUNIT; NEURONS; FIBERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Ozawa, S Gunma Univ, Sch Med, Gunma 3718511, Japan Gunma Univ Gunma Japan 3718511 v, Sch Med, Gunma 3718511, Japan
Citazione:
M. Lino et al., "Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmannglia", SCIENCE, 292(5518), 2001, pp. 926-929

Abstract

Glial cells express a variety of neurotransmitter receptors, Notably, Bergmann glial cells in the cerebellum have Ca2+-permeable alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) assembled without the GluR2 subunit, To elucidate the role of these Ca2-permeable AMPARs, we converted them into Ca2+-impermeable receptors by adenoviral-mediated delivery of the GluR2 gene. This conversion retracted theglial processes ensheathing synapses on Purkinje cell dendritic spines andretarded the removal of synaptically released glutamate, Furthermore, it caused multiple innervation of Purkinje cells by the climbing fibers. Thus, the glial Ca2+-permeable AMPARs are indispensable for proper structural andfunctional relations between Bergmann glia and glutamatergic synapses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 07:13:06