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Titolo:
Cytokine control in human endometrium
Autore:
Kelly, RW; King, AE; Critchley, HOD;
Indirizzi:
MRC, Human Reprod Sci Unit, Ctr Reprod Biol, Edinburgh EH3 9ET, Midlothian, Scotland MRC Edinburgh Midlothian Scotland EH3 9ET h EH3 9ET, Midlothian, Scotland
Titolo Testata:
REPRODUCTION
fascicolo: 1, volume: 121, anno: 2001,
pagine: 3 - 19
SICI:
1470-1626(200101)121:1<3:CCIHE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; LEUKEMIA INHIBITORY FACTOR; MESSENGER-RIBONUCLEIC-ACID; TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; ENDOTHELIAL GROWTH-FACTOR; MONOCYTE CHEMOATTRACTANT PROTEIN-1; ANTIINFLAMMATORY DRUGS NSAIDS; PROSTAGLANDIN E-2 PRODUCTION; HUMAN UTERINE ENDOMETRIUM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
206
Recensione:
Indirizzi per estratti:
Indirizzo: Kelly, RW MRC, Human Reprod Sci Unit, Ctr Reprod Biol, 37 Chalmers St, Edinburgh EH39ET, Midlothian, Scotland MRC 37 Chalmers St Edinburgh MidlothianScotland EH3 9ET cotland
Citazione:
R.W. Kelly et al., "Cytokine control in human endometrium", REPRODUCT, 121(1), 2001, pp. 3-19

Abstract

Cytokines within endometrium participate in both menstruation and implantation but also contribute to the defence mechanisms of the mucosal epithelium. Endometrium is under the control of steroid hormones, particularly progesterone and, thus, control of cytokines by this steroid is important. Although appreciable numbers of progesterone receptors are not found in endometrial leucocytes, progesterone can modulate cytokines by acting on uterine cells expressing the receptor. The NF kappaB pathway is important in the control of cytokine synthesis and can modulate production of chemokines, matrixmetalloproteinases and the inducible prostaglandin synthesis enzyme COX-2. NF kappaB activity can be inhibited by progesterone by either stimulating synthesis of I kappaB, the molecule that restrains NF kappaB in the cytosol, or after binding to the nuclear receptor, competing with NF kappaB for recognition sites on the relevant gene. In this way, progesterone can limit pro-inflammatory pathways. The major palliatives for endometrial dysfunctions such as menorrhagia and dysmenorrhoea have been the non-steroidal anti-inflammatory drugs that inhibit prostaglandin synthesis. Prostaglandins have major effects on cytokine production but the direct action of prostaglandinE on leucocytes is not a pro-inflammatory response but is to stimulate interleukin 10 and inhibit interleukin 12 synthesis. The likely effect of the non-steroidal anti-inflammatory drugs is on the cells surrounding the smallblood vessels, where a synergistic action between prostaglandin and chemokine will induce leucocyte entry and activation leading to lysis of connective tissue and menstruation. At the time of implantation, tight control of cytokine synthesis is required. Although leukaemia inhibitory factor is essential to implantation, the mouse knockout models show that the prostaglandin system is also essential but that there are mutually supportive pathways that compensate for the knockout of many cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 09:03:46