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Titolo:
Significance of incorporating measures of sperm production and function into rat toxicology studies
Autore:
Perreault, SD; Cancel, AM;
Indirizzi:
US EPA, Reprod Toxicol Div, NHEERL, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 NHEERL, Res Triangle Pk, NC 27711 USA Univ N Carolina, Toxicol Program, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 ogram, Chapel Hill, NC 27599 USA
Titolo Testata:
REPRODUCTION
fascicolo: 2, volume: 121, anno: 2001,
pagine: 207 - 216
SICI:
1470-1626(200102)121:2<207:SOIMOS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDIDYMAL SPERM; IN-VITRO; HYPERACTIVATED MOTILITY; REPRODUCTIVE TOXICANTS; FERTILIZING ABILITY; AUTOMATED-ANALYSIS; HUMAN SPERMATOZOA; ACROSOME REACTION; MAMMALIAN SPERM; END-POINTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Perreault, SD US EPA, Reprod Toxicol Div, NHEERL, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 iangle Pk, NC 27711 USA
Citazione:
S.D. Perreault e A.M. Cancel, "Significance of incorporating measures of sperm production and function into rat toxicology studies", REPRODUCT, 121(2), 2001, pp. 207-216

Abstract

The rat is the preferred species for reproductive toxicity testing. The inclusion of measures of rat sperm quality, such as motility and morphology, into reproductive test protocols often increases the sensitivity of the test to detect effects, and provides the toxicologist and risk assessor with valuable information about the nature of the reproductive toxicity of the test substance. Technical advances in computer-aided sperm analysis have madeit possible to evaluate motion characteristics of rat spermatozoa. This technology can provide an objective means of classifying the motion of rat spermatozoa as progressive or non-progressive, as required in test protocols. More specific tests of rat sperm function are being applied for the purpose of evaluating modes and mechanisms of toxicant action. Computer-aided sperm analysis can be used to evaluate sperm motion during cultures that support sperm capacitation and to identify hyperactivated spermatozoa. Under thesame culture conditions, acrosome-specific stains can be used to identify effects of toxicants on the acrosome reaction. These approaches, in combination with in vitro fertilization in rats, can pinpoint sperm functional deficits and thereby assist the toxicologist in addressing hypotheses regarding the cellular-molecular bases of toxicant-induced male infertility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 21:05:04