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Titolo:
Potential roles of decidual prolactin in early pregnancy
Autore:
Jabbour, HN; Critchley, HOD;
Indirizzi:
MRC, Human Reprod Sci Unit, Edinburgh EH3 9ET, Midlothian, Scotland MRC Edinburgh Midlothian Scotland EH3 9ET h EH3 9ET, Midlothian, Scotland MRC, Dept Reprod & Dev Sci, Edinburgh EH3 9ET, Midlothian, Scotland MRC Edinburgh Midlothian Scotland EH3 9ET h EH3 9ET, Midlothian, Scotland
Titolo Testata:
REPRODUCTION
fascicolo: 2, volume: 121, anno: 2001,
pagine: 197 - 205
SICI:
1470-1626(200102)121:2<197:PRODPI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOMETRIAL STROMAL CELLS; NONPREGNANT HUMAN ENDOMETRIUM; ACTIVATED PROTEIN-KINASE; MENSTRUAL-CYCLE; MESSENGER-RNA; PROGESTERONE-RECEPTOR; ENDOTHELIAL-CELLS; HIGH-AFFINITY; PRL RECEPTOR; SHORT FORMS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Jabbour, HN MRC, Human Reprod Sci Unit, 37 Chalmers St, Edinburgh EH3 9ET,Midlothian,Scotland MRC 37 Chalmers St Edinburgh Midlothian Scotland EH3 9ET tland
Citazione:
H.N. Jabbour e H.O.D. Critchley, "Potential roles of decidual prolactin in early pregnancy", REPRODUCT, 121(2), 2001, pp. 197-205

Abstract

Successful establishment of pregnancy is dependent on uterine receptivity at the time of trophoblast invasion and implantation. The endometrium undergoes morphological and Functional differentiation during the mid- to late secretory phase of the menstrual cycle in preparation for such an event. These changes are orchestrated by ovarian steroid hormones. However, local autocrine-paracrine signalling at the deciduo-placental interface is crucial for successful establishment of pregnancy. One key cytokine that may regulate many functions in implantation is prolactin. Prolactin is secreted by thedecidualized endometrium at the time of predicted conception and, in the event of pregnancy, local expression and secretion of prolactin persists until term. Prolactin mediates its effect on target cells through interaction with single-pass transmembrane receptors. Localization of the sites of expression of the prolactin receptor indicates that the cytokine may regulate an array of functions in the pregnant uterus that are crucial in implantation and early pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:55:59