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Titolo:
Effect of finadyne on oestradiol-induced ovarian oxytocin and uterine PGF(2 alpha) secretory systems on day 15 after oestrus in ovarian autotransplanted ewes
Autore:
Al-Matubsi, HY; Fairclough, RJ;
Indirizzi:
Univ Cincinnati, Coll Med, Dept Obstet & Gynecol, Cincinnati, OH 45267 USAUniv Cincinnati Cincinnati OH USA 45267 Gynecol, Cincinnati, OH 45267 USA Victoria Univ Technol, Dept Biomed Sci, Melbourne, Vic, Australia VictoriaUniv Technol Melbourne Vic Australia Melbourne, Vic, Australia
Titolo Testata:
REPRODUCTION
fascicolo: 3, volume: 121, anno: 2001,
pagine: 429 - 434
SICI:
1470-1626(200103)121:3<429:EOFOOO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVINE CORPUS-LUTEUM; STEROIDOGENIC CELL-TYPES; PROSTAGLANDIN RELEASE; INDUCED LUTEOLYSIS; G/H SYNTHASE-2; ESTROUS-CYCLE; ESTRADIOL; PROGESTERONE; SHEEP; NEUROPHYSIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Al-Matubsi, HY Univ Cincinnati, Coll Med, Dept Obstet & Gynecol, POB 670526, Cincinnati, OH 45267 USA Univ Cincinnati POB 670526 Cincinnati OH USA 45267 5267 USA
Citazione:
H.Y. Al-Matubsi e R.J. Fairclough, "Effect of finadyne on oestradiol-induced ovarian oxytocin and uterine PGF(2 alpha) secretory systems on day 15 after oestrus in ovarian autotransplanted ewes", REPRODUCT, 121(3), 2001, pp. 429-434

Abstract

This study was undertaken to determine whether induction of ovarian oxytocin after oestradiol treatment on day 15 after oestrus is mediated through prostaglandin secretion by blocking prostaglandin synthesis using finadyne, an inhibitor of the cyclo-oxygenase pathway. Nine ewes with ovarian autotransplants were assigned randomly to receive an i.m. injection of either oestradiol benzoate (50 mug) in peanut oil (n = 5) or oestradiol benzoate plus finadyne (2.2 mg kg(-1)) (n = 4) at 3 h intervals starting at the time of oestradiol injection. Blood samples were collected from the ovarian and contralateral jugular veins at 30 min intervals for 6 h before and at 15 min intervals for up to 9 h after the oestradiol and finadyne injections. The secretion rate of ovarian progesterone remained high in all ewes, thus indicating the presence of a functional corpus luteum. Peripheral oestradiol concentrations were significantly (P < 0.001) higher during the 9 h after oestradiol injection in both groups. None of the oestradiol-finadyne-treated ewesshowed significant pulses in either ovarian oxytocin secretion or release of the prostaglandin F-2 alpha metabolite 13,14-dihydro-15-keto PGF(2 alpha) (PCFM) after injections. In ewes treated with oestradiol only, at least one detectable pulse of ovarian oxytocin and jugular PCFM was observed with mean +/- SEM amplitude of 17.7 +/- 7.29 ng min(-1) and 237.18 +/- 43.13 pg ml(-1), respectively. The areas under the curve for ovarian oxytocin and jugular PGFM pulses were significantly increased after oestradiol treatment. These findings demonstrate that initiation of the arachidonic acid cascade is important for the secretion of oxytocin after oestrogen treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 23:59:52