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Titolo:
Pituitary tumours
Autore:
Davis, JRE; Farrell, WE; Clayton, RN;
Indirizzi:
Univ Manchester, Fac Med, Endocrine Sci Res Grp, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England Univ Keele, Postgrad Med Sch, Ctr Cell & Mol Med, Stoke On Trent ST4 7QB, Staffs, England Univ Keele Stoke On Trent Staffs England ST4 7QB ST4 7QB, Staffs, England
Titolo Testata:
REPRODUCTION
fascicolo: 3, volume: 121, anno: 2001,
pagine: 363 - 371
SICI:
1470-1626(200103)121:3<363:PT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFORMING GENE PTTG; GROWTH-FACTOR; INFREQUENT MUTATIONS; MEN1 GENE; IN-VIVO; ADENOMAS; EXPRESSION; TUMORS; HORMONE; PATHOGENESIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Davis, JRE Univ Manchester, Fac Med, Endocrine Sci Res Grp, Manchester M139PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT ancs, England
Citazione:
J.R.E. Davis et al., "Pituitary tumours", REPRODUCT, 121(3), 2001, pp. 363-371

Abstract

Pituitary tumours are a common type of intracranial neoplasm and, depending on the cell type of origin, have diverse endocrine and reproductive effects. The developmental biology of the different cell types is understood to result from a sequential activation of a cascade of transcription factors, and mutations in these factors result in various forms of hypopituitarism. Tumours in the pituitary gland arise from activation of dominantly acting oncogenes such as gsp, or from loss of function of a series of tumour suppressor genes such as MEN1. Abnormal patterns of DNA methylation may be implicated in the allelic losses that cause tumour suppressor gene silencing. Thedifferent clinically recognized types of pituitary tumour are currently treated by medical therapies such as dopamine and somatostatin agonists, surgery or radiotherapy. However, these treatments are not entirely satisfactory and recent advances in gene therapy may offer valuable new therapeutic opportunities for patients with aggressive tumours that fail to respond to traditional approaches.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:25:49