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Titolo:
Association of endometrosis in horses with differentiation of periglandular myofibroblasts and changes of extracellular matrix proteins
Autore:
Walter, I; Handler, J; Reifinger, M; Aurich, C;
Indirizzi:
Univ Vet Med Vienna, Inst Histol & Embryol, A-1210 Vienna, Austria Univ Vet Med Vienna Vienna Austria A-1210 mbryol, A-1210 Vienna, Austria Univ Vet Med Vienna, Clin Obstet Gynaecol & Androl, A-1210 Vienna, AustriaUniv Vet Med Vienna Vienna Austria A-1210 Androl, A-1210 Vienna, Austria Univ Vet Med Vienna, Inst Pathol & Forens Vet Med, A-1210 Vienna, Austria Univ Vet Med Vienna Vienna Austria A-1210 et Med, A-1210 Vienna, Austria Univ Vet Med Vienna, Ctr Artificial Inseminat & Embryo Transfer, A-1210 Vienna, Austria Univ Vet Med Vienna Vienna Austria A-1210 ansfer, A-1210 Vienna, Austria
Titolo Testata:
REPRODUCTION
fascicolo: 4, volume: 121, anno: 2001,
pagine: 581 - 586
SICI:
1470-1626(200104)121:4<581:AOEIHW>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MENSTRUAL-CYCLE; EXPRESSION; COLLAGEN; CELLS; FIBRONECTIN; TENASCIN; PREGNANCY; INTEGRINS; UTERUS; BREAST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Walter, I Univ Vet Med Vienna, Inst Histol & Embryol, Vet Pl 1, A-1210 Vienna, Austria Univ Vet Med Vienna Vet Pl 1 Vienna Austria A-1210 nna, Austria
Citazione:
I. Walter et al., "Association of endometrosis in horses with differentiation of periglandular myofibroblasts and changes of extracellular matrix proteins", REPRODUCT, 121(4), 2001, pp. 581-586

Abstract

Periglandular fibrosis and cystic dilation of uterine glands are associated with equine endometrosis. The presence of extracellular matrix proteins (collagen type I, III and IV, laminin and fibronectin) in healthy and endometrotic specimens was demonstrated by immunohistochemistry. The distributionof collagen I, but not collagen III, was dependent on the stage of the oestrous cycle. The arrangement of collagen I and collagen III in endometroticspecimens was similar to that in normal endometrium. In periglandular fibrosis, collagen IV, laminin and fibronectin deposition outside the basement membrane was observed. In these regions, stromal cells were characterized immuno-histochemically as myofibroblasts because of their expression of a-smooth muscle actin, and occasionally tropomyosin and desmin. Periglandular differentiation of contractile cells could be interpreted as a reaction to support the extrusion of secretions in cystic dilated glands. Moreover, the changes of extracellular matrix proteins are characteristic for neoplastic lesions, although further development of endometrosis to benign or malignant tumours is not known in horses. Knowledge of the factors responsible for these fibroblastic modulations may be the key to explaining the pathogenesis of endometrosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:28:36