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Titolo:
Effects of bupropion SR on anterior paralimbic function during waking and REM sleep in depression: preliminary findings using [F-18]-FDG PET
Autore:
Nofzinger, EA; Berman, S; Fasiczka, A; Miewald, JM; Meltzer, CC; Price, JC; Sembrat, RC; Wood, A; Thase, ME;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 sychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh, Sch Med, Dept Radiol, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Radiol, Pittsburgh, PA 15213 USA
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 2, volume: 106, anno: 2001,
pagine: 95 - 111
SICI:
0925-4927(20010410)106:2<95:EOBSOA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; EMISSION COMPUTERIZED-TOMOGRAPHY; MEDIAL PREFRONTAL CORTEX; AUTOMATED ALGORITHM; GLUCOSE-METABOLISM; AFFECTIVE-DISORDER; MAJOR DEPRESSION; FDG PET; BRAIN; DEPRIVATION;
Keywords:
regional cerebral glucose metabolism; depression; anterior cingulate cortex; medical prefrontal cortex; REM sleep; bupropion SR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Nofzinger, EA Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA Western Psychiat Inst & Clin 3811 OHara St Pittsburgh PA USA 15213
Citazione:
E.A. Nofzinger et al., "Effects of bupropion SR on anterior paralimbic function during waking and REM sleep in depression: preliminary findings using [F-18]-FDG PET", PSYCH RES-N, 106(2), 2001, pp. 95-111

Abstract

This study sought to clarify the effects of bupropion SR on anterior paralimbic function in depressed patients by studying changes in the activation of these structures from waking to REM sleep both before and after treatment. Twelve depressed patients underwent concurrent EEG sleep studies and [F-18]fluoro-2-deoxy-D-glucose ([F-18]-FDG) positron emission tomography (PET)scans during waking and during their second REM period of sleep before andafter treatment with bupropion SR. Nine subjects completed pre- and post-treatment waking PET studies. Five subjects completed pre- and post-treatment waking and REM sleep PET studies. Bupropion SR treatment did not suppresselectrophysiologic measures of REM sleep, nor did it alter an indirect measure of global metabolism during either waking or REM sleep. Bupropion SR treatment reversed the previously observed deficit in anterior cingulate, medial prefrontal cortex and right anterior insula activation from waking to REM sleep. In secondary analyses, this effect was related to a reduction inwaking relative metabolism in these structures following treatment in the absence of a significant effect on REM sleep relative metabolism. The implications of these findings for the relative importance of anterior paralimbic function in REM sleep in depression and for the differential effects of anti-depressant treatment on brain function during waking vs. REM sleep are discussed. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 09/04/20 alle ore 10:48:49