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Titolo:
Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and[F-18]deuteroaltanserin
Autore:
Soares, JC; van Dyck, CH; Tan, PZ; Zoghbi, SS; Garg, P; Soufer, R; Baldwin, RM; Fujita, M; Staley, JK; Fu, X; Amici, L; Seibyl, J;
Indirizzi:
Yale Univ, Sch Med, VA Connecticut Healthcare Syst, Dept Psychiat, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 Syst, Dept Psychiat, W Haven, CT 06516 USA
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 2, volume: 106, anno: 2001,
pagine: 81 - 93
SICI:
0925-4927(20010410)106:2<81:ROIVBM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; F-18 ALTANSERIN; BINDING; SEROTONIN; SETOPERONE; LIGAND; SCHIZOPHRENIA; DEPRESSION; INVIVO; QUANTIFICATION;
Keywords:
reproducibility; serotonin; 5-HT2A receptors; receptor imaging; neuroimaging; brain imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Soares, JC Univ Pittsburgh, Western Psychiat Inst & Clin, Med Ctr, 3811 OHara St, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 15213 USA
Citazione:
J.C. Soares et al., "Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and[F-18]deuteroaltanserin", PSYCH RES-N, 106(2), 2001, pp. 81-93

Abstract

The test/retest reproducibility of brain measures of 5-HT2A receptors withpositron emission tomography (PET) and [F-18]deuteroaltanserin was examined in a group of eight healthy human subjects. PET measures of 5-HT2A receptors were obtained under an equilibrium paradigm, with a 40-min PET acquisition starting approximately at 300 min (308 +/- 11 min) after bolus plus constant infusion of the radiotracer. Three brain outcome measures were obtained at equilibrium, V-3 (ratio of specific brain uptake to free parent plasma concentration of radiotracer), V-3' (ratio of specific brain uptake to total parent plasma concentration) and RT (ratio of specific to non-displaceable brain uptakes). V-3' and RT had high test/retest reproducibility, as measured by mean intra-sudject% change for cortical brain areas of 14.1 and 11.0%, respectively. They also had high reliability, as measured by mean intra-class correlation coefficients (ICC) for cortical brain areas of 0.86 and 0.88, respectively. V-3 had low test/retest reproducibility, due to high variability in the measures of free parent tracer in plasma. This study supports the feasibility of equilibrium imaging of 5-HT2A receptors with PET and [F-18]deuteroaltanserin. The equilibrium imaging, method with [F-18]deuteroaltanserin allows a single acquisition and blood measurement to provide an image whose pixel values equal a receptor volume of distribution. Since the single image pixel values are proportional to receptor densities, the images can be used in pixel-by-pixel statistical methods, such as SPM, to assess the distribution and density of 5-HT2A receptors in neuropsychiatric disorders. (C) 2001 Published by Elsevier Science Ireland Ltd.

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Documento generato il 26/01/20 alle ore 00:39:19