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Titolo:
Anatomical MRI study of basal ganglia in bipolar disorder patients
Autore:
Brambilla, P; Harenski, K; Nicoletti, MA; Mallinger, AG; Frank, E; Kupfer, DJ; Keshavan, MS; Soares, JC;
Indirizzi:
Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 sychiat, Pittsburgh, PA 15213 USA Univ Pavia, IRCCS Matteo, Dept Psychiat, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 tteo, Dept Psychiat, I-27100 Pavia, Italy Univ Pittsburgh, Sch Med, Dept Pharmacol, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA ed, Dept Pharmacol, Pittsburgh, PA USA Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Psychol, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 eurosci, Pittsburgh, PA 15260 USA
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 2, volume: 106, anno: 2001,
pagine: 65 - 80
SICI:
0925-4927(20010410)106:2<65:AMSOBG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; POSITRON EMISSION TOMOGRAPHY; SUBCORTICAL SIGNAL HYPERINTENSITIES; ELDERLY DEPRESSED-PATIENTS; NEURO-BEHAVIORAL CHANGES; MAJOR DEPRESSION; MOOD DISORDERS; IN-VIVO; CAUDATE VOLUME; NEUROPSYCHIATRIC DISORDERS;
Keywords:
caudate; putamen; globus pallidus; mood disorders; brain imaging; magnetic resonance imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Soares, JC Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, 3811 OHara St, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 15213 USA
Citazione:
P. Brambilla et al., "Anatomical MRI study of basal ganglia in bipolar disorder patients", PSYCH RES-N, 106(2), 2001, pp. 65-80

Abstract

This study examined possible anatomical abnormalities in basal ganglia structures in bipolar disorder patients. Caudate and putamen gray matter volumes, and globus pallidus total volume were measured with magnetic resonance imaging (MRI) in 22 DSM-IV bipolar patients (age +/- S.D. = 36 +/- 10 years; eight drug-free and 14 lithium monotherapy patients) and 22 matched healthy control subjects (age +/- S.D. = 38 +/- 10 years). No significant differences were found between bipolar patients and healthy control subjects for any of the basal ganglia measures (t-tests, P > 0.05). Age was inversely correlated with left putamen volumes in patients (R = -0.44, P = 0.04), but not in healthy control subjects (R = -0.33. P = 0.14). Older patients ( > 36years old) had a significantly larger left globus pallidus than younger ones (less than or equal to 36 years old) (ANOVA, P = 0.01). In a multiple regression analysis, after entering age as independent variable, the length of illness predicted smaller left putamen volumes, explaining 10.4% of the variance (F = 4.07, d.f. = 2, P = 0.03). No significant effects of episode type, number of prior episodes, or gender were found in any basal ganglia measurements (ANOVA, P > 0.05). In conclusion, our findings indicate that thebasal ganglia may be anatomically preserved in bipolar patients. This is in contrast to available findings for unipolar disorder. However, our findings also suggest that age and length of illness may have significant effectson basal ganglia structures in bipolar patients, which may be more pronounced among bipolar I patients, and of relevance for the pathophysiology of the disorder. (C) 2001 Elsevier Science Ireland Ltd. Ail rights reserved.

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Documento generato il 22/01/20 alle ore 06:36:22