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Titolo:
Polymorphisms of renin-angiotensin system genes in childhood IgA nephropathy
Autore:
Maruyama, K; Yoshida, M; Nishio, H; Shirakawa, T; Kawamura, T; Tanaka, R; Nakamura, H; Iijima, K; Yoshikawa, N;
Indirizzi:
Wakayama Med Univ, Dept Pediat, Wakayama 6418510, Japan Wakayama Med UnivWakayama Japan 6418510 Pediat, Wakayama 6418510, Japan Kobe Univ, Sch Med, Fac Hlth Sci, Kobe, Hyogo 650, Japan Kobe Univ Kobe Hyogo Japan 650 Med, Fac Hlth Sci, Kobe, Hyogo 650, Japan Kobe Univ, Sch Med, Dept Publ Hlth, Kobe, Hyogo 650, Japan Kobe Univ KobeHyogo Japan 650 ed, Dept Publ Hlth, Kobe, Hyogo 650, Japan Kyoto Univ, Ctr Student Hlth, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Ctr Student Hlth, Kyoto, Japan Hyogo Prefectural Awaji Hosp, Dept Pediat, Sumoto, Hyogo, Japan Hyogo Prefectural Awaji Hosp Sumoto Hyogo Japan at, Sumoto, Hyogo, Japan Kobe Univ, Sch Med, Dept Pediat, Kobe, Hyogo 650, Japan Kobe Univ Kobe Hyogo Japan 650 h Med, Dept Pediat, Kobe, Hyogo 650, Japan
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 4, volume: 16, anno: 2001,
pagine: 350 - 355
SICI:
0931-041X(200104)16:4<350:PORSGI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME GENE; ESSENTIAL-HYPERTENSION; DELETION POLYMORPHISM; A NEPHROPATHY; PROGRESSION; ASSOCIATION; GLOMERULONEPHRITIS; IMMUNOGLOBULIN; CHILDREN; THERAPY;
Keywords:
IgA nephropathy; children; angiotensinogen gene; angiotensin-converting enzyme gene; urinary protein excretion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshikawa, N Wakayama Med Univ, Dept Pediat, 811-1 Kimiidera, Wakayama 6418510, Japan Wakayama Med Univ 811-1 Kimiidera Wakayama Japan 6418510 pan
Citazione:
K. Maruyama et al., "Polymorphisms of renin-angiotensin system genes in childhood IgA nephropathy", PED NEPHROL, 16(4), 2001, pp. 350-355

Abstract

We investigated whether polymorphisms of the renin-angiotensin system genes are involved in IgA nephropathy in Japanese children. We identified the M235T polymorphism of the angiotensinogen (AGT) gene, the I/D polymorphisms of the angiotensin-converting enzyme (ACE) gene, and the A1166C polymorphism of the angiotensin II type 1 receptor gene in 95 Japanese children with IgA nephropathy and 99 healthy Japanese adults. There were no differences inthe genotype and allele frequencies of these genes between patients with IgA nephropathy and controls. Urinary protein excretion at the time of biopsy was significantly greater in patients with the TT genotype of the AGT gene than in those with the MM/MT genotypes of the AGT gene (1.32 +/-1.42 versus 0.75 +/-0.78 g/day; P=0.01) and in patients with the ID/DD genotypes of the ACE gene than in those with the II genotype of the ACE gene (1.45 +/-1.50 versus 0.63 +/-0.56 g/day; P=0.001). Thus, the TT genotype of the AGT gene and the ID/DD genotype of the ACE gene are associated with increased severity of proteinuria, suggesting that AGT and ACE gene polymorphisms may play a significant role in the progression of IgA nephropathy in Japanese children.

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Documento generato il 19/09/20 alle ore 17:37:37