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Titolo:
Birth weight has no influence on glomerular number and volume
Autore:
Jones, SE; Nyengaard, JR; Flyvbjerg, A; Bilous, RW; Marshall, SM;
Indirizzi:
Med Sch Newcastle Upon Tyne, Sch Clin Med Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Med Sch Newcastle Upon Tyne Newcastle Upon Tyne Tyne & Wear England NE2 4HH Aarhus Univ, Stereol Res Lab, DK-8000 Aarhus, Denmark Aarhus Univ AarhusDenmark DK-8000 reol Res Lab, DK-8000 Aarhus, Denmark Aarhus Univ, Inst Expt Clin Res, DK-8000 Aarhus, Denmark Aarhus Univ Aarhus Denmark DK-8000 xpt Clin Res, DK-8000 Aarhus, Denmark Aarhus Univ, Med Dept M, DK-8000 Aarhus, Denmark Aarhus Univ Aarhus Denmark DK-8000 , Med Dept M, DK-8000 Aarhus, Denmark
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 4, volume: 16, anno: 2001,
pagine: 340 - 345
SICI:
0931-041X(200104)16:4<340:BWHNIO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAUTERINE GROWTH-RETARDATION; DEPENDENT DIABETES-MELLITUS; RAT; HYPERTENSION; SIZE; EXPOSURE; AGE;
Keywords:
low birth weight; glomerular number; glomerular volume;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, SE Med Sch Newcastle Upon Tyne, Dept Med, Framlington Pl, NewcastleUpon TyneNE2 4HH, Tyne & Wear, England Med Sch Newcastle Upon Tyne Framlington Pl Newcastle Upon Tyne Tyne & Wear England NE2 4HH
Citazione:
S.E. Jones et al., "Birth weight has no influence on glomerular number and volume", PED NEPHROL, 16(4), 2001, pp. 340-345

Abstract

It has been proposed that low birth weight (LBW) results in a reduction inglomerular number that may, in turn, predispose an individual to develop hypertension in adulthood. Glomerular number is reduced in animal models of intra-uterine malnutrition using a variety of techniques. However, the relevance of such extreme models to man is uncertain. The purpose of this studywas to evaluate whether animals with naturally occurring LBW. which have not received any manipulation in utero, have a reduction in glomerular number, altered glomerular volume and abnormal urine albumin excretion. Litters from female rats delivering at term on the same day were weighed and sexed at birth. From each litter 2 males with the lowest birth weight (LBW n=18) and 2 males with a birth weight closest to the litter mean [normal birth weight (NBW) n=18] were selected and cross-fostered onto periparturient lactating dams. LBW rats weighed 6.7 +/-0.6 g compared with 7.2 +/-0.6 g for NEWrats (P=0.03). After weaning all rats were weighed weekly and underwent metabolic studies at 4, 8, 12 and 16 weeks. Following perfusion fixation, glomerular number and mean glomerular volume were estimated using standard stereological techniques. There was no significant difference between LBW and NEW rats with respect to glomerular number (24 499 +/-2 078 vs. 24 825 +/-1818), mean glomerular volume and urine albumin excretion, and no rats had a glomerular number outside the normal range. This study suggests that naturally occurring LBW has little influence on renal development, glomerular number and volume.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 15:06:25