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Titolo:
Clinical value of electrocardiographic parameters in genotyped individualswith familial long QT syndrome
Autore:
Moennig, G; Schulze-Bahr, E; Wedekind, H; Borggrefe, M; Funke, H; Toelle, M; Kirchhof, P; Eckardt, L; Assmann, G; Breithardt, G; Haverkamp, W;
Indirizzi:
Univ Munster, Dept Cardiol & Angiol, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 & Angiol, D-48149 Munster, Germany Univ Munster, Inst Arteriosclerosis Res, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 rosis Res, D-48149 Munster, Germany
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 4, volume: 24, anno: 2001,
parte:, 1
pagine: 406 - 415
SICI:
0147-8389(200104)24:4<406:CVOEPI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR REPOLARIZATION; CARDIAC-ARREST; DISPERSION; RISK; INTERVALS; GENE; PCR;
Keywords:
long QT syndrome; mutations; QT dispersion; QT product; repolarization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Moennig, G Univ Munster, Dept Cardiol & Angiol, Albert Schweitzer Str 33, D-48149 Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48149
Citazione:
G. Moennig et al., "Clinical value of electrocardiographic parameters in genotyped individualswith familial long QT syndrome", PACE, 24(4), 2001, pp. 406-415

Abstract

Rate corrected QT interval (QTc) and QT dispersion (QTd) have been suggested as markers of an increased propensity to arrhythmic even ts and efficacyof therapy in patients with long QT syndrome (LQTS). To evaluate whether QTc and QTd correlate to genetic status and clinical symptoms in LQTS patients and their relatives, ECGs of 116 genotyped individuals were analyzed. JTc and QTc were longest in symptomatic patients (n = 28). Both QTd and JTd were significantly higher in symptomatic patients than in asymptomatic (n = 29) or unaffected family members (n = 59). The product of QTd/JTd and QTc/JTc was significantly different among all three groups. Both dispersion and product put additional and independent power on identification of mutation carriers when adjusted for sex and age in a logistic regression analysis. Thus, symptomatic patients with LQTS show marked inhomogenity of repolarization in the surface EGG. QT dispersion and QT product might be helpful in finding LQTS mutation carriers and might serve as additional ECG tools to identify asymptomatic LQTS patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:44:36