Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Synthesis and DNA cleavage activity of a novel bleomycin A(5) glycoconjugate
Autore:
Choudhury, AK; Tao, ZF; Hecht, SM;
Indirizzi:
Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA Univ Virginia Charlottesville VA USA 22901 Charlottesville, VA 22901 USA Univ Virginia, Dept Biol, Charlottesville, VA 22901 USA Univ Virginia Charlottesville VA USA 22901 Charlottesville, VA 22901 USA
Titolo Testata:
ORGANIC LETTERS
fascicolo: 9, volume: 3, anno: 2001,
pagine: 1291 - 1294
SICI:
1523-7060(20010503)3:9<1291:SADCAO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC ASIALOGLYCOPROTEIN RECEPTOR; RNA DEGRADATION; HIGH-AFFINITY; HYDROLASE; MOIETY; BINDING; LIGANDS; MODELS; LIVER; A(2);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hecht, SM Univ Virginia, Dept Chem, Mccormick Rd, Charlottesville, VA 22901 USA Univ Virginia Mccormick Rd Charlottesville VA USA 22901 2901 USA
Citazione:
A.K. Choudhury et al., "Synthesis and DNA cleavage activity of a novel bleomycin A(5) glycoconjugate", ORG LETT, 3(9), 2001, pp. 1291-1294

Abstract

[GRAPHICS]To explore the possibility of modifying bleomycin in a fashion that could alter its physiological distribution in a therapeutic setting, a new analogue of bleomycin has been prepared. This analogue is intended to target the asialoglycoprotein receptor on liver cells. Critically, despite the large C-substituent, the bleomycin conjugate was found to degrade DNA in the same fashion as bleomycin A(5) itself, and with only modestly decreased efficiency.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 13:20:26