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Titolo:
The 2-(N-formyl-N-methyl)aminoethyl group as a potential phosphate/thiophosphate protecting group in solid-phase oligodeoxyribonucleotide synthesis
Autore:
Grajkowski, A; Wilk, A; Chmielewski, MK; Phillips, LR; Beaucage, SL;
Indirizzi:
US FDA, Ctr Biol Evaluat & Res, Div Therapeut Prot, Bethesda, MD 20892 USAUS FDA Bethesda MD USA 20892 , Div Therapeut Prot, Bethesda, MD 20892 USA NCI, Biol Tresting Branch, Dev Therapeut Program, Frederick, MD 21701 USA NCI Frederick MD USA 21701 Dev Therapeut Program, Frederick, MD 21701 USA
Titolo Testata:
ORGANIC LETTERS
fascicolo: 9, volume: 3, anno: 2001,
pagine: 1287 - 1290
SICI:
1523-7060(20010503)3:9<1287:T2GAAP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHATE PROTECTION; CHLORIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Beaucage, SL US FDA, Ctr Biol Evaluat & Res, Div Therapeut Prot, 8800 Rockville Pike, Bethesda, MD 20892 USA US FDA 8800 Rockville Pike Bethesda MD USA 20892 MD 20892 USA
Citazione:
A. Grajkowski et al., "The 2-(N-formyl-N-methyl)aminoethyl group as a potential phosphate/thiophosphate protecting group in solid-phase oligodeoxyribonucleotide synthesis", ORG LETT, 3(9), 2001, pp. 1287-1290

Abstract

[GRAPHICS]The 2-(N-formyl-N-methyl)aminoethyl deoxyribonucleoside phosphoramidite 1 has been synthesized and used in the solid-phase synthesis of an octadecathymidylic acid as a cost-efficient monomer for potential application in the preparation of therapeutic oligonucleotides, The 2-(N-formyl-N-methyl)aminoethyl group can be cleaved from oligonucleotides according to a unique thermolytic cyclodeesterification process at pH 7.0. In addition to being cost-effective, the use of 1 simplifies oligonucleotide postsynthesis processingby eliminating the utilization of concentrated ammonium hydroxide in oligonucleotide deprotection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:43:27