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Titolo:
The human obesity gene map: The 2000 update
Autore:
Perusse, L; Chagnon, YC; Weisnagel, SJ; Rankinen, T; Snyder, E; Sands, J; Bouchard, C;
Indirizzi:
Univ Laval, Dept Social & Prevent Med, Div Kinesiol, Fac Med, St Foy, PQ G1K 7P4, Canada Univ Laval St Foy PQ Canada G1K 7P4 , Fac Med, St Foy, PQ G1K 7P4, Canada Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USALouisiana State Univ Baton Rouge LA USA 70808 , Baton Rouge, LA 70808 USA
Titolo Testata:
OBESITY RESEARCH
fascicolo: 2, volume: 9, anno: 2001,
pagine: 135 - 169
SICI:
1071-7323(200102)9:2<135:THOGMT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; BODY-MASS INDEX; BETA(3)-ADRENERGIC RECEPTOR GENE; BARDET-BIEDL-SYNDROME; GOLABI-BEHMEL-SYNDROME; ALBRIGHT-HEREDITARY-OSTEODYSTROPHY; DEPENDENT DIABETES-MELLITUS; PRADER-WILLI-SYNDROME; FACTOR-ALPHA GENE; INSULIN-RESISTANCE SYNDROME;
Keywords:
association; linkages; QTL; genes; Mendelian syndrome;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
361
Recensione:
Indirizzi per estratti:
Indirizzo: Perusse, L Univ Laval, Dept Social & Prevent Med, Div Kinesiol, Fac Med, PEPS Bldg, St Foy, PQ G1K 7P4, Canada Univ Laval PEPS Bldg St Foy PQ Canada G1K 7P4 Q G1K 7P4, Canada
Citazione:
L. Perusse et al., "The human obesity gene map: The 2000 update", OBES RES, 9(2), 2001, pp. 135-169

Abstract

This report constitutes the seventh update of the human obesity gene map incorporating published results up to the end of October 2000. Evidence fromthe rodent and human obesity cases caused by single-gene mutations, Mendelian disorders exhibiting obesity as a clinical feature, quantitative trait loci uncovered in human genome-wide scans and in cross-breeding experimentsin various animal models, and association and linkage studies with candidate genes and other markers are reviewed. Forty-seven human cases of obesitycaused by single-gene mutations in six different genes have been reported in the literature to date. Twenty-four Mendelian disorders exhibiting obesity as one of their clinical manifestations have now been mapped. The numberof different quantitative trait loci reported from animal models currentlyreaches 115. Attempts to relate DNA sequence variation in specific genes to obesity phenotypes continue to grow, with 130 studies reporting positive associations with 48 candidate genes. Finally, 59 loci have been linked to obesity indicators in genomic scans and other linkage study designs. The obesity gene map reveals that putative loci affecting obesity-related phenotypes can be found on all chromosomes except chromosome Y. A total of 54 new loci have been added to the map in the past 12 months and the number of genes, markers, and chromosomal regions that have been associated or linked with human obesity phenotypes is now above 250. Likewise, the number of negative studies, which are only partially reviewed here, is also on the rise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:29:10