Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Subclinical hypothyroidism in obese patients: Relation to resting energy expenditure, serum leptin, body composition, and lipid profile
Autore:
Tagliaferri, M; Berselli, ME; Calo, G; Minocci, A; Savia, G; Petroni, ML; Viberti, GC; Liuzzi, A;
Indirizzi:
Ospedale San Giuseppe, Inst Ricovero & Cura Carattere Sci, Ist Auxologico Italiano, Clin Nutr Lab, I-28900 Verbania, Italy Ospedale San Giuseppe Verbania Italy I-28900 ab, I-28900 Verbania, Italy Guys Hosp, Guys St Thomass & Kings Sch Med, Metab Med Unit, London SE1 9RT, England Guys Hosp London England SE1 9RT Metab Med Unit, London SE1 9RT, England Ospedale San Giuseppe, Inst Ricovero & Cura Carattere Sci, Ist Auxologico Italiano, Div Endocrinol & Metabol Dis, I-28900 Verbania, Italy Ospedale San Giuseppe Verbania Italy I-28900 is, I-28900 Verbania, Italy
Titolo Testata:
OBESITY RESEARCH
fascicolo: 3, volume: 9, anno: 2001,
pagine: 196 - 201
SICI:
1071-7323(200103)9:3<196:SHIOPR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOELECTRICAL-IMPEDANCE ASSESSMENT; L-THYROXINE THERAPY; THYROID-HORMONES; RISK FACTOR; WOMEN; DISEASE; LIPOPROTEIN(A); REPLACEMENT; DYSFUNCTION; CHOLESTEROL;
Keywords:
thyroid function; risk factors; energy expenditure; fat-free mass; body mass index;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Liuzzi, A Ospedale San Giuseppe, Inst Ricovero & Cura Carattere Sci, Ist Auxologico Italiano, Div Endocrinol, I-28900 Verbania, Italy Ospedale San Giuseppe Verbania Italy I-28900 0 Verbania, Italy
Citazione:
M. Tagliaferri et al., "Subclinical hypothyroidism in obese patients: Relation to resting energy expenditure, serum leptin, body composition, and lipid profile", OBES RES, 9(3), 2001, pp. 196-201

Abstract

Objective: To evaluate whether subclinical hypothyroidism (SH) affects resting energy expenditure (REE) as well as body composition, lipid profile, and serum leptin in obese patients. Research Methods and Procedures: A total of 108 obese patients with SH defined as normal free thyroxine levels and thyroid-stimulating hormone (TSH) values of >4.38 muU/ml (mean +/- 2 SD of the values of our reference group of obese patients with normal thyroid function) were compared with a group of 131 obese patients matched for age, sex, and body mass index (BMI) but with normal TSH levels. We assessed estimated daily caloric intake by 7-day recall, REE by indirect calorimetry, body composition by bioelectrical impedance analysis, serum leptin by radioimmunoassay, and lipid profile (i.e., total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides). Results: All of the variables measured were not different between the euthyroid obese patients and those with SH. In a multiple regression model withREE expressed for kilo-grams of fat free: mass (REE/kgFFM) as a dependent variable and percentage of fat mass, BMI, waist-to-hip ratio, age, TSH, free thyroxine, serum leptin, and caloric intake as independent variables, only percentage of fat mass was significantly correlated with REE/kgFFM in both groups. Tn the SH group only, BMI, waist-to-hip ratio, age, and TSH were related to REE/kgFFM and explained 69.5% of its variability. After dividingthe patients with SH using a cutoff TSH value of 5.7 muU/ml, which represents 3 SD above the mean of TSH levels of the group of obese patients with normal thyroid function, only REE/kgFFM was significantly different and lower in the group of more severely hypothyroid patients. Discussion: In patients with obesity, SH affects energy expenditure only when TSH: is clearly above the normal range; it does not change body composition and lipid profile. We suggest that, at least in obese patients, evaluation of TSH levels may be useful to rule out a possible impairment of resting energy expenditure due to a reduced peripheral effect of thyroid hormones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:32:07