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Titolo:
Blood pressure and pulse pressure during long-term weight loss in the obese: The Swedish Obese Subjects (SOS) Intervention Study
Autore:
Sjostrom, CD; Peltonen, M; Sjostrom, L;
Indirizzi:
Sahlgrens Univ Hosp, Dept Anesthesia & Intensive Care, SOS Secretariat, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Med, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Anesthesiol & Intens Care, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden
Titolo Testata:
OBESITY RESEARCH
fascicolo: 3, volume: 9, anno: 2001,
pagine: 188 - 195
SICI:
1071-7323(200103)9:3<188:BPAPPD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR MORTALITY; MORBIDLY OBESE; HYPERTENSION; SURGERY; REDUCTION; ARTERY; DEATH;
Keywords:
aging; weight control; clinical trials; gastroplasty; gastric bypass;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sjostrom, CD Sahlgrens Univ Hosp, Dept Anesthesia & Intensive Care, SOS Secretariat, Vita Strakey 15, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Vita Strakey 15 Gothenburg Sweden S-41345
Citazione:
C.D. Sjostrom et al., "Blood pressure and pulse pressure during long-term weight loss in the obese: The Swedish Obese Subjects (SOS) Intervention Study", OBES RES, 9(3), 2001, pp. 188-195

Abstract

Objective: Recently we reported a complete relapse in the blood pressure (BP) of obese subjects despite a maintained 16% weight loss over 8 years. This relapse is now analyzed as a function of several variables. Pulse pressure (PP) is an independent risk factor of cardiovascular mortality. We now examine the development of PP in the obese and whether it can be modified byweight-reducing gastric surgery. Research Methods and Procedures: A total of 1157 patients treated with gastric surgery and 1031 obese controls (body mass index of 41.0 +/- 4.6 kg/m(2) [mean +/- SD], age 48 +/- 6 years) were followed for 5.5 +/- 2.1 (range 3 to 10) years. To separate the effect of weight change from effect of timeon BP, the patients were divided in cohorts based on follow-up time. Results: Gastric surgery resulted in a maximum weight loss after 1 year that was followed by a moderate relapse. After 5.5 years, weight loss in the intervention group was 18 +/- 11% of initial body weight. Very little weight change was seen in controls. Systolic BP decreased in the intervention group during the first 6 months but had relapsed to control values at last examination. The adjusted change in PP was +4.7 mm Hg in obese controls but +2.9 mm Hg in the intervention group (p < 0.001). Final BP values were more closely related to follow-up time and ongoing weight increase than to initial body weight ol initial weight loss. Discussion: Effects of time (aging) and weight change per year on BP can be separated. An early increase in PP could be observed in the obese. This increase could be modified by weight-reducing gastric surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:19:37