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Titolo:
Magnetization transfer MRS
Autore:
Leibfritz, D; Dreher, W;
Indirizzi:
Univ Bremen, Fachbereich 2, D-28334 Bremen, Germany Univ Bremen Bremen Germany D-28334 achbereich 2, D-28334 Bremen, Germany
Titolo Testata:
NMR IN BIOMEDICINE
fascicolo: 2, volume: 14, anno: 2001,
pagine: 65 - 76
SICI:
0952-3480(200104)14:2<65:MTM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HETEROGENEOUS SPIN SYSTEMS; OFF-RESONANCE-IRRADIATION; XENOPUS-LAEVIS OOCYTES; PROTON NMR RELAXATION; IN-VIVO OBSERVATION; CREATINE-KINASE; LONGITUDINAL MAGNETIZATION; SELECTIVE SATURATION; TRANSFER CONTRAST; ASTROGLIAL CELLS;
Keywords:
magnetic resonance spectroscopy; magnetization transfer; chemical exchange; spin diffusion; creatine; lactate; ethanol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Leibfritz, D Univ Bremen, Fachbereich 2, NW 2, D-28334 Bremen, Germany Univ Bremen NW 2 Bremen Germany D-28334 8334 Bremen, Germany
Citazione:
D. Leibfritz e W. Dreher, "Magnetization transfer MRS", NMR BIOMED, 14(2), 2001, pp. 65-76

Abstract

This review deals with magnetization transfer (MT) effects observed in in vivo NMR spectroscopy. The basic experimental methods of MT experiments, the underlying kinetic mechanisms as well as the evaluation of measured data by fits to two- or three-pool models are described, Experimental results ofboth P-31 and H-1 in vivo MRS are reviewed showing the potential of MT experiments to characterize kinetic equilibrium reactions. This includes reactions where all involved components are MR visible, as well as situations where one indirectly measures pools of bound spins which cannot directly be observed in vive. In particular, MT effects are described which have been observed in in vivo H-1 NMR spectra measured on the animal or human brain or on skeletal muscle. Possible mechanisms for the strong MT effects observed for the signals of creatine/phosphocreatine, lactate, alcohol and other metabolites are discussed. It is also emphasized that MT effects caused by water suppression techniques may lead to systematic errors in the quantification of in vive H-1 NMR spectra. Copyright (C) 2001 John Wiley & Sons, Ltd.

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Documento generato il 03/06/20 alle ore 09:05:25