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Titolo:
Comparison of the spinal anti-nociceptive effects of ES-242-1 and MK-801, two different NMDA antagonists, in rats
Autore:
Hamada, F; Noutsuka, H; Hamada, Y; Goto, H;
Indirizzi:
Tokyo Med Univ, Dept Otorhinolaryngol, Shinjuku Ku, Tokyo 1600023, Japan Tokyo Med Univ Tokyo Japan 1600023 ol, Shinjuku Ku, Tokyo 1600023, Japan Saga Med Sch, Dept Anesthesiol & Crit Care Med, Saga 8498501, Japan Saga Med Sch Saga Japan 8498501 iol & Crit Care Med, Saga 8498501, Japan Tokyo Med Univ, Dept Anesthesiol, Shinjuku Ku, Tokyo 1600023, Japan Tokyo Med Univ Tokyo Japan 1600023 ol, Shinjuku Ku, Tokyo 1600023, Japan Univ Kansas, Med Ctr, Dept Anesthesiol, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 esthesiol, Kansas City, KS 66160 USA
Titolo Testata:
NEUROSCIENCE RESEARCH
fascicolo: 1, volume: 40, anno: 2001,
pagine: 61 - 66
SICI:
0168-0102(200105)40:1<61:COTSAE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; FORMALIN TEST; ANTINOCICEPTIVE ACTIONS; CENTRAL SENSITIZATION; RECEPTOR ANTAGONISTS; MORPHINE; AGENTS;
Keywords:
ES-242-1; MK-801; NMDA antagonist; formalin test; anti-nociception; inflammatory pain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Hamada, F Tokyo Med Univ, Dept Otorhinolaryngol, Shinjuku Ku, 6-7-1 Nishi Shinjuku, Tokyo 1600023, Japan Tokyo Med Univ 6-7-1 Nishi Shinjuku Tokyo Japan 1600023 , Japan
Citazione:
F. Hamada et al., "Comparison of the spinal anti-nociceptive effects of ES-242-1 and MK-801, two different NMDA antagonists, in rats", NEUROSCI RE, 40(1), 2001, pp. 61-66

Abstract

The purpose of this study was to determine whether ES-242-1, a novel N-methyl-D-aspartate (NMDA) receptor antagonist of microbial origin, has anti-nociception at the spinal level and to evaluate how its anti-nociceptive effect differs from that of MK-801, a non-competitive NMDA receptor antagonist. Agents were injected intrathecally (0.1, 1.0 and 10 mug) through a previously implanted PE tube in rats. Formalin (2%, 100 mul) was injected subcutaneously into the left hindpaw 15 min after each antagonist administration. Licking time as a nociceptive behavior was measured in three stages after formalin-injection, such as early phase (0-9 min), late first phase (10-29 min) and late second phase (30-60 min). In the early phase, the largest dose of ES-242-1 significantly decreased total licking time, although MK-801 didnot show any significant reduction. With the treatment of 1.0 and 10 mug MK-801, total licking time in both late first and second phases was significantly suppressed, although the smallest dose (0.1 mug) of ES-242-1 showed asignificant reduction in the late second phase. These results indicate that ES-242-1 is highly effective against tonic pain, such as inflammatory pain. (C) 2001 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

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Documento generato il 22/01/20 alle ore 19:06:58