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Titolo:
Cortical spreading depression during streptozotocin-induced hyperglycaemiain nutritionally normal and early-malnourished rats
Autore:
Costa-Cruz, RRG; Guedes, RCA;
Indirizzi:
Univ Fed Pernambuco, Dept Nutr, BR-50670901 Recife, PE, Brazil Univ Fed Pernambuco Recife PE Brazil BR-50670901 BC901 Recife, PE, Brazil Univ Fed Pernambuco, Dept Fisiol & Farmacol, BR-50670901 Recife, PE, Brazil Univ Fed Pernambuco Recife PE Brazil BR-50670901 BC901 Recife, PE, Brazil
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 303, anno: 2001,
pagine: 177 - 180
SICI:
0304-3940(20010511)303:3<177:CSDDSH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE HYPOGLYCEMIA; GLUCOSE-UTILIZATION;
Keywords:
hyperglycaemia; hypoglycaemia; malnutrition; spreading depression; Streptozotocin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Guedes, RCA Univ Fed Pernambuco, Dept Nutr, BR-50670901 Recife, PE, BrazilUniv Fed Pernambuco Recife PE Brazil BR-50670901 BCPE, Brazil
Citazione:
R.R.G. Costa-Cruz e R.C.A. Guedes, "Cortical spreading depression during streptozotocin-induced hyperglycaemiain nutritionally normal and early-malnourished rats", NEUROSCI L, 303(3), 2001, pp. 177-180

Abstract

Cortical spreading depression (SD) was investigated in adult rats during Streptozotocin (STZ)-induced hyperglycaemia (group S; n = 13). SD velocitiesof propagation were significantly lower than in the controls injected onlywith vehicle solution (group V; n = 17). In contrast, rats rendered hypoglycaemic by food restriction + insulin for 3 days (group HG; n = 9) presented SD velocities significantly higher than controls; this effect was reversed by injecting glucose during the recording session. SD velocity in early-malnourished rats was not different during STZ-hyperglycaemia (group MS; n =8) compared with previously-malnourished rats injected with vehicle (groupMV; n = 9). The data indicate an inverse relationship between glycaemia changes and SD propagation in well-nourished rats. Early malnutrition seems to abolish the effect of STZ-hyperglycaemia on SD. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:51:31