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Titolo:
2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induces apoptosis in the dorsal midbrain of zebrafish embryos by activation of arylhydrocarbon receptor
Autore:
Dong, W; Teraoka, H; Kondo, S; Hiraga, T;
Indirizzi:
Rakuno Gakuen Univ, Sch Vet Med, Dept Toxicol, Ebetsu, Hokkaido 069, JapanRakuno Gakuen Univ Ebetsu Hokkaido Japan 069 Ebetsu, Hokkaido 069, Japan Mitsubishi Kasei Inst Life Sci, Machida, Tokyo 194, Japan Mitsubishi KaseiInst Life Sci Machida Tokyo Japan 194 , Tokyo 194, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 303, anno: 2001,
pagine: 169 - 172
SICI:
0304-3940(20010511)303:3<169:2378IA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD; DANIO-RERIO; MICE; IDENTIFICATION; EXPOSURE; TOXICITY; STRESS; PCBS;
Keywords:
Ah receptor; apoptosis; developmental toxicology; dioxin; embryo; 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; zebrafish;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Teraoka, H Rakuno Gakuen Univ, Sch Vet Med, Dept Toxicol, Ebetsu, Hokkaido069, Japan Rakuno Gakuen Univ Ebetsu Hokkaido Japan 069 kkaido 069, Japan
Citazione:
W. Dong et al., "2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induces apoptosis in the dorsal midbrain of zebrafish embryos by activation of arylhydrocarbon receptor", NEUROSCI L, 303(3), 2001, pp. 169-172

Abstract

Neurotoxic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) has not been fully elucidated, despite the known potent agonist of arylhydrocarbon receptor (AhR), which activation induces cytochrome P450 1A and several representative toxicities of halogenated aromatic hydrocarbons. In the present study, the effects of TCDD on cell death in zebrafish embryos (Danio rerio) during the early stage of development were investigated. As shown by terminal transferase-mediated nick-end-labeling staining, TCDD exposure significantly increased the occurrence of pycnotic cell death (PCD), especially in the dorsal midbrain (optic tectum). The ultrastructures of these pycnotic cells showed apoptotic features such as condensation and cleavage of chromatin. TCDD-induced PCD was mimicked by beta-naphthoflavone (AhR agonist), and inhibited by alpha-naphthoflavone (AhR antagonist). These results suggest that AhR activation can induce apoptosis in the central nervous system during development. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:32:10