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Titolo:
Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: Possible implications for behaviour
Autore:
Welberg, LAM; Seckl, JR; Holmes, MC;
Indirizzi:
Univ Edinburgh, Western Gen Hosp, Mol Endocrinol Lab, Mol Med Ctr, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH4 2XU Midlothian, Scotland Univ Edinburgh, Western Gen Hosp, Dept Clin Neurosci, Mol Med Ctr, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH4 2XU Midlothian, Scotland
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 104, anno: 2001,
pagine: 71 - 79
SICI:
0306-4522(2001)104:1<71:PGPOBC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORCED SWIM TEST; CONGENITAL ADRENAL-HYPERPLASIA; MESSENGER-RIBONUCLEIC-ACID; CORONARY HEART-DISEASE; ADULT-RATS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; MINERALOCORTICOID RECEPTOR; STRESS INCREASES; GENE-EXPRESSION; BLOOD-PRESSURE;
Keywords:
rat; dexamethasone; birth weight; prenatal stress; anxiety;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Holmes, MC Univ Edinburgh, Western Gen Hosp, Mol Endocrinol Lab, Mol Med Ctr, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH4 2XU Scotland
Citazione:
L.A.M. Welberg et al., "Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: Possible implications for behaviour", NEUROSCIENC, 104(1), 2001, pp. 71-79

Abstract

Glucocorticoids may underlie the association between low birth weight and adult disorders such as hyperten sion, type 2 diabetes and affective dysfunction. We investigated the behavioural and molecular consequences of two paradigms of prenatal dexamethasone administration in rats. Rats received dexamethasone (100 mug/kg per day) throughout pregnancy (DEX 1 -3), in the last third of pregnancy only (DEX3) or vehicle. Both dexamethasone treatments reduced birth weight. only DEX1-3 offspring had reduced body weight in adulthood. In adult offspring, both prenatal dexamethasone paradigms reduced exploratory behaviour in an open held. In contrast, only DEX3 reduced exploration in an elevated plus-maze and impaired behavioural responses and learning in a forced-swim test. This behavioural inhibition mag. reflect increased baseline corticotrophin-releasing hormone mRNA levels (30% higher) in thecentral nucleus of the amygdala in both dexamethasone-exposed groups. Adult DEX3 offspring also showed increased corticotrophin-releasing hormone mRNA with unaltered glucocorticoid receptor mRNA in the hypothalamic paraventricular nucleus and reduced hippocampal glucocorticoid- and mineralocorticoid receptor mRNA expression, suggesting reduced hippocampal sensitivity to glucocorticoid suppression of the stress axis. In contrast, DEX1-3 rats had no changers in hippocampal corticosteroid receptors. but showed increased mRNA levels for both receptors in the basolateral nucleus of the amygdala. From this data we suggest that prenatal glucocorticoid exposure programs behavioural inhibition perhaps, via increased amygdalar corticotrophin-releasing hormone levels, while DEX3 also impairs coping and learning in aversive situations. possibly via altered hippocampal corticosteroid receptor levels, Overexposure to glucocorticoids, especially late in gestation, may explain the link between reduced early growth and adult affective dysfunction. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/12/18 alle ore 22:58:45