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Titolo:
Normalization of circulating leptin levels by fasting improves the reproductive function in obese OLETF female rats
Autore:
Watanobe, H; Yoneda, M; Kohsaka, A; Kakizaki, Y; Suda, T; Schioth, HB;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Internal Med 3, Hirosaki, Aomori, Japan Hirosaki Univ Hirosaki Aomori Japan ernal Med 3, Hirosaki, Aomori, Japan Dokkyo Univ, Sch Med, Dept Gastroenterol, Mibu, Tochigi 32102, Japan Dokkyo Univ Mibu Tochigi Japan 32102 oenterol, Mibu, Tochigi 32102, Japan Uppsala Univ, Dept Neurosci, Uppsala, Sweden Uppsala Univ Uppsala Sweden ppsala Univ, Dept Neurosci, Uppsala, Sweden Melacure Therapeut, Uppsala, Sweden Melacure Therapeut Uppsala SwedenMelacure Therapeut, Uppsala, Sweden
Titolo Testata:
NEUROPEPTIDES
fascicolo: 1, volume: 35, anno: 2001,
pagine: 45 - 49
SICI:
0143-4179(200102)35:1<45:NOCLLB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUTEINIZING-HORMONE; PROLACTIN SURGES; TESTOSTERONE; INFERTILITY; CYCLES; WEIGHT; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Watanobe, H Int Univ Hlth & Welf, Clin Res Ctr, Div Internal Med, 2600-1 Kitakanemaru,Otawara, Tochigi 3248501, Japan Int Univ Hlth & Welf 2600-1 Kitakanemaru Otawara Tochigi Japan 3248501
Citazione:
H. Watanobe et al., "Normalization of circulating leptin levels by fasting improves the reproductive function in obese OLETF female rats", NEUROPEPTID, 35(1), 2001, pp. 45-49

Abstract

In order to examine a possible detrimental effect of hyperleptinemia on the reproductive system, we examined whether a decrease in circulating leptinlevels by fasting affects the estradiol/progesterone-induced luteinizing hormone (LH) and prolactin (PRL) surges in genetically obese OLETF (Otsuka-Long-Evans-Tokushima-Fatty) rats. Experiments were performed on both normally fed and 3-day starved groups from ovariectomized OLETF rats and their controls LETO (Long-Evans-Tokushima-Otsuka). Starved LETO rats, whose leptin levels were less than 0.5 ng/ml, did not show a significant surge of either LH or PRL. Normally fed OLETF rats, whose leptin levels were 9.7 +/- 1.8 ng/ml, showed a significant but small surge for both LH and PRL. Interestingly, starved OLETF rats, whose leptin levels (4.1 +/- 0.7 ng/ml) were similarto those in normally fed LETO rats (3.3 +/- 0.4ng/ml), had significantly greater surges of both hormones than normally fed OLETF group. This study demonstrates for the first time that the normalization of circulating leptin levels in female OLETF rats augments the steroid-induced LH and PRL surges,and also suggests a deleterious effect of hyperleptinemia on the reproductive axis. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 08:57:39