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Titolo:
Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation
Autore:
Steward, O; Worley, PF;
Indirizzi:
Univ Calif Irvine, Coll Med, Reeve Irvine Res Ctr, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 rvine Res Ctr, Irvine, CA 92697 USA Univ Calif Irvine, Coll Med, Dept Anat & Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 t & Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine, Coll Med, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 obiol & Behav, Irvine, CA 92697 USA Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA
Titolo Testata:
NEURON
fascicolo: 1, volume: 30, anno: 2001,
pagine: 227 - 240
SICI:
0896-6273(200104)30:1<227:STONSA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCAL PROTEIN-SYNTHESIS; LONG-TERM POTENTIATION; IMMEDIATE-EARLY GENE; MESSENGER-RNA; DENDRITES; PATHWAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Steward, O Univ Calif Irvine, Coll Med, Reeve Irvine Res Ctr, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 tr, Irvine, CA 92697 USA
Citazione:
O. Steward e P.F. Worley, "Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation", NEURON, 30(1), 2001, pp. 227-240

Abstract

Newly synthesized Are mRNA is selectively targeted to synapses that have experienced particular patterns of activity. Here, we demonstrate that the targeting requires NMDA receptor activation. Are expression was induced by an electroconvulsive seizure, and the newly synthesized mRNA was then targeted to synaptic sites by activating the perforant path projections to the dentate gyrus. When micropipette electrodes containing NMDA receptor antagonists (MK801 or APV) were positioned in the dentate gyrus during the stimulation period, newly synthesized Are mRNA was transported into dendrites but did not localize in the activated lamina; instead, the mRNA remained diffusely distributed. AMPA receptor antagonists (CNQX) blocked targeting of Are mRNA in a small region, and mGluR antagonists (MCPG) did not affect localization. These results demonstrate that NMDA receptor activation is required for the targeting of Are mRNA to active synapses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:25:45