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Titolo:
Extrasynaptic release of dopamine in a retinal neuron: Activity dependenceand transmitter modulation
Autore:
Puopolo, M; Hochstetler, SE; Gustincich, S; Wightman, RM; Raviola, E;
Indirizzi:
Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Neurobiol, Boston, MA 02115 USA Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Chem, Chapel Hill, NC 27599 USA
Titolo Testata:
NEURON
fascicolo: 1, volume: 30, anno: 2001,
pagine: 211 - 225
SICI:
0896-6273(200104)30:1<211:ERODIA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT RETINA; CHROMAFFIN CELLS; QUANTAL SIZE; GANGLION NEURONS; CAT RETINA; EXTRACELLULAR ELECTROPHYSIOLOGY; ACCUMULATING NEURONS; HIPPOCAMPAL-NEURONS; CALCIUM CHANNELS; SUBSTANTIA-NIGRA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Raviola, E Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 urobiol, Boston, MA 02115 USA
Citazione:
M. Puopolo et al., "Extrasynaptic release of dopamine in a retinal neuron: Activity dependenceand transmitter modulation", NEURON, 30(1), 2001, pp. 211-225

Abstract

Extrasynaptic release of dopamine is well documented, but its relation to the physiological activity of the neuron is unclear. Here we show that in absence of presynaptic active zones, solitary cell bodies of retinal dopaminergic neurons release by exocytosis packets of similar to 40,000 molecules of dopamine at irregular intervals and low frequency. The release is triggered by the action potentials that the neurons generate in a rhythmic fashion upon removal of all synaptic influences and therefore depends upon the electrical events at the neuronal surface. Furthermore, it is stimulated by kainate and abolished by GABA and quinpirole, an agonist at the D-2 dopaminereceptor. Since the somatic receptors for these ligands are extrasynaptic,we suggest that the composition of the extracellular fluid directly modulates extrasynaptic release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:47:57