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Titolo:
Fluctuations in brain glucose concentration during behavioral testing: Dissociations between brain areas and between brain and blood
Autore:
McNay, EC; McCarty, RC; Gold, PE;
Indirizzi:
Univ Illinois, Dept Psychol, Champaign, IL 61820 USA Univ Illinois Champaign IL USA 61820 ept Psychol, Champaign, IL 61820 USA Univ Virginia, Dept Psychol, Charlottesville, VA 22903 USA Univ Virginia Charlottesville VA USA 22903 Charlottesville, VA 22903 USA Yale Univ, Dept Psychol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 v, Dept Psychol, New Haven, CT 06520 USA
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 3, volume: 75, anno: 2001,
pagine: 325 - 337
SICI:
1074-7427(200105)75:3<325:FIBGCD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS-ALTERNATION PERFORMANCE; RAT-BRAIN; TRIPLE DISSOCIATION; MORPHINE INJECTIONS; NEURONAL-ACTIVITY; SPATIAL TASK; IN-VIVO; MICRODIALYSIS; MEMORY; HIPPOCAMPUS;
Keywords:
glucose; memory; striatum; extracellular fluid; microdialysis; spatial memory; blood glucose; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Gold, PE Univ Illinois, Dept Psychol, 603 E Daniel St, Champaign, IL 61820USA Univ Illinois 603 E Daniel St Champaign IL USA 61820 IL 61820 USA
Citazione:
E.C. McNay et al., "Fluctuations in brain glucose concentration during behavioral testing: Dissociations between brain areas and between brain and blood", NEUROBIOL L, 75(3), 2001, pp. 325-337

Abstract

Traditional beliefs about two aspects of glucose regulation in the brain have been challenged by recent findings. First, the absolute level of glucose in the brain's extracellular fluid appears to be lower than previously thought. Second, the level of glucose in brain extracellular fluid is less stable than previously believed. In vivo brain microdialysis was used, according to the method of zero net flux, to determine the basal concentration ofglucose in the extracellular fluid of the striatum in awake, freely movingrats for comparison with recent hippocampal measurements. In addition, extracellular glucose levels in both the hippocampus and the striatum were measured before, during, and after behavioral testing in a hippocampus-dependent spontaneous alternation task. In the striatum, the resting extracellularglucose level was 0.71 mM, approximately 70% of the concentration measuredpreviously in the hippocampus. Consistent with past findings, the hippocampal extracellular glucose level decreased by up to 30 +/- 4% during testing; no decrease, and in fact a small increase (9 +/- 3%), was seen in the striatum. Blood glucose measurements obtained during the same testing procedure and following administration of systemic glucose at a dose known to enhance memory in this task revealed a dissociation in glucose level fluctuations between the blood and both striatal and hippocampal extracellular fluid. These findings suggest, first, that glucose is compartmentalized within thebrain and, second, that one mechanism by which administration of glucose enhances memory performance is via provision of increased glucose supply from the blood specifically to those brain areas involved in mediating that performance. (C) 2001 Academic Press.

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Documento generato il 05/07/20 alle ore 13:21:40