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Titolo:
Long-term memory formation in the chick requires mobilization of ryanodine-sensitive intracellular calcium stores
Autore:
Salinska, EJ; Bourne, RC; Rose, SPR;
Indirizzi:
Open Univ, Dept Biol Sci, Brain & Behav Res Grp, Milton Keynes MK7 6AA, Bucks, England Open Univ Milton Keynes Bucks England MK7 6AA nes MK7 6AA, Bucks, England Med Res Ctr, Dept Neurochem, PL-02106 Warsaw, Poland Med Res Ctr Warsaw Poland PL-02106 pt Neurochem, PL-02106 Warsaw, Poland
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 3, volume: 75, anno: 2001,
pagine: 293 - 302
SICI:
1074-7427(200105)75:3<293:LMFITC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DAY-OLD CHICK; HIPPOCAMPAL CA1 NEURONS; PASSIVE-AVOIDANCE; THAPSIGARGIN BLOCKS; NMDA RECEPTORS; FOREBRAIN; BRAIN; POTENTIATION; GLUTAMATE; DANTROLENE;
Keywords:
passive avoidance training; NMDA; AMPA; dantrolene; synaptoneurosomes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Bourne, RC Open Univ, Dept Biol Sci, Brain & Behav Res Grp, Walton Hall, Milton Keynes MK7 6AA, Bucks, England Open Univ Walton Hall Milton Keynes Bucks England MK7 6AA gland
Citazione:
E.J. Salinska et al., "Long-term memory formation in the chick requires mobilization of ryanodine-sensitive intracellular calcium stores", NEUROBIOL L, 75(3), 2001, pp. 293-302

Abstract

Training chicks (Gallus domesticus) on a one-trial passive avoidance task results in transient and time-dependent enhanced increases in N-methyl-D-aspartate- or alpha -amino-3-hydroxy-5-methyl-4-isoxazoleprop intracellular calcium concentration in synaptoneurosomes isolated from a specific forebrain region, the intermediate medial hyperstriatum ventrale. This increase could result from either calcium entry from the extracellular medium or from mobilization of intracellular calcium stores. We have therefore examined theeffects of dantrolene, an inhibitor of calcium release from the intracellular ryanodine-sensitive store, on these processes. Dantrolene, 50 nmol per hemisphere injected intracerebrally 30 min pre- or 30 min posttraining, blocked longer term memory for the passive avoidance task, whereas memory for the task was unaffected when dantrolene was injected at earlier or later times. Preincubation of synaptoneurosomes, isolated from the intermediate hyperstriatum ventrale IO min after training, with 100 nM dantrolene abolishedthe enhanced training-induced increase in intracellular calcium concentration elicited by 0.5 mM N-methyl-D-aspartate. By contrast, the training-induced enhancement of the alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionate-stimulated increase in intracellular calcium concentration in synaptoneurosomes prepared 6 h posttraining was unaffected by preincubation with dantrolene, which was not amnestic at this time. Calcium release from ryanodine-sensitive intracellular stores may thus be a necessary stage in the early phase of the molecular cascade leading to the synaptic modulation required for long-term memory storage. (C) 2000 Academic Press.

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Documento generato il 26/01/20 alle ore 10:09:29