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Titolo:
Functional recovery of skilled forelimb use in rats obliged to use the impaired limb after grafting of the frontal cortex lesion with homotopic fetalcortex
Autore:
Riolobos, AS; Heredia, M; de la Fuente, JA; Criado, JM; Yajeya, J; Campos, J; Santacana, M;
Indirizzi:
Univ Salamanca, Fac Med, Dept Fisiol & Farmacol, Inst Neurociencias Castilla & Leon, Salamanca 37007, Spain Univ Salamanca Salamanca Spain 37007 illa & Leon, Salamanca 37007, Spain Univ Complutense Somosaguas, Fac Psicol, Madrid, Spain Univ Complutense Somosaguas Madrid Spain uas, Fac Psicol, Madrid, Spain CSIC, Inst Cajal, E-28002 Madrid, Spain CSIC Madrid Spain E-28002CSIC, Inst Cajal, E-28002 Madrid, Spain
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 3, volume: 75, anno: 2001,
pagine: 274 - 292
SICI:
1074-7427(200105)75:3<274:FROSFU>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT-RATS; MOTOR CORTEX; CORTICAL TRANSPLANTS; BRAIN TRANSPLANTS; PREFRONTAL CORTEX; NEOCORTICAL TRANSPLANTS; NIGROSTRIATAL DOPAMINE; TISSUE-TRANSPLANTS; SUBSTANTIA NIGRA; NEONATAL DAMAGE;
Keywords:
frontal cortex; forelimb motor cortex; transplantation; paw-reaching for-food task; open field test; muscular strength test; adult rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Riolobos, AS Univ Salamanca, Fac Med, Dept Fisiol & Farmacol, Inst Neurociencias Castilla & Leon, Avenida Alfonso X Sabio S-N, Salamanca 37007, SpainUniv Salamanca Avenida Alfonso X Sabio S-N Salamanca Spain 37007
Citazione:
A.S. Riolobos et al., "Functional recovery of skilled forelimb use in rats obliged to use the impaired limb after grafting of the frontal cortex lesion with homotopic fetalcortex", NEUROBIOL L, 75(3), 2001, pp. 274-292

Abstract

The long-term effect of transplanting embryonic frontal cortex into a unilateral frontal cortex lesion has been studied in adult rats. Before surgery, activity in an open field, muscular strength of both forelimbs, and performance in a paw-reaching-for-food task were scored in 26 rats. In 21 animals a unilateral cortex lesion was then made in the forelimb motor area of the hemisphere contralateral to the preferred paw in the paw-reaching-for-food task, while the other 5 animals were sham-operated. On retesting, the lesion animals changed the preferred paw. A solid homotopic transplant of embryonic tissue (embryonic day 17) was then placed in the lesion cavity in 11 of the lesion rats. Three months later neither lesion alone nor Lesion plustransplantation affected open field behavior and muscular strength, but the lesion permanently affected performance in the paw-reaching-for-food task, as shown by a change of preferred paw and a functional deficit in the pawcontralateral to the lesion. Transplantation ameliorated the deficits caused by the lesion, but this was only evident when animals were forced to reach with the paw contralateral to the lesion plus transplant. The behavioralresults were independent of the size of the lesion and graft. Connections between graft and host tissue were studied by means of the fluorescent tracer 1,1'-dioctadecyl-3,3,3'3'-tetramethylindocarbocyanine perchlorate (DiI). A dense array of labeled fibers was found in the host cortex adjacent to the transplant. The results suggest that functional recovery depends on grafting but is only evident when the animal is obliged to use the affected limb. (C) 2001 Academic Press.

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Documento generato il 27/01/20 alle ore 01:26:25