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Titolo:
CAMKII inhibition in the parabrachial nuclei elicits conditioned taste aversion in rats
Autore:
Sacchetti, B; Baldi, E; Tassoni, G; Bielavska, E;
Indirizzi:
Acad Sci Czech Republ, Inst Physiol, CR-14220 Prague 4, Czech Republic Acad Sci Czech Republ Prague Czech Republic 4 0 Prague 4, Czech Republic Univ Florence, Dept Physiol Sci, Florence, Italy Univ Florence Florence Italy lorence, Dept Physiol Sci, Florence, Italy
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 3, volume: 75, anno: 2001,
pagine: 253 - 261
SICI:
1074-7427(200105)75:3<253:CIITPN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-II; INTRACEREBRAL INJECTION; BLOCKS ACQUISITION; MEMORY FORMATION; LEARNING ALTERS; MUTANT MICE; CALMODULIN; PHOSPHORYLATION; CHELERYTHRINE; TETRODOTOXIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Bielavska, E Acad Sci Czech Republ, Inst Physiol, Videnska 1083, CR-14220 Prague 4, Czech Republic Acad Sci Czech Republ Videnska 1083 Prague Czech Republic 4
Citazione:
B. Sacchetti et al., "CAMKII inhibition in the parabrachial nuclei elicits conditioned taste aversion in rats", NEUROBIOL L, 75(3), 2001, pp. 253-261

Abstract

The conditioned taste aversion (CTA) paradigm was used to assess the role of Ca2+/calmodulin-dependent protein kinase (CAMKII) in associative learning. KN62, a specific inhibitor of CAMKII, was injected into the parabrachialnuclei (PBN) either immediately after saccharin drinking (CS) or after saccharin drinking and i.p. injection of LiCl (US). Injection of KN62 into thePEN after saccharin drinking elicited clear CTA (Exp. 1). This effect was dosage-dependent and site-specific (Exp. 2). The results are discussed in relation with an earlier report showing that CTA acquisition is disrupted byinjection of Ca2+/phospholipid-dependent protein kinase (PKC! inhibitor chelerythrine into the PBN during CS-US interval. It is suggested that the principal serine/threonine kinases play different roles in CTA learning: whereas PKC activity is necessary for the gustatory short-term memory formation, CAMKII acts similarly to the US itself-an unexpected role of CAMKII in associative learning, (C) 2001 Academic Press.

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Documento generato il 05/04/20 alle ore 06:15:13