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Titolo:
Intrahippocampal scopolamine impairs both acquisition and consolidation ofcontextual fear conditioning
Autore:
Wallenstein, GV; Vago, DR;
Indirizzi:
Univ Utah, Program Neurosci, Dept Psychol, Cognit Neurobiol Lab, Salt LakeCity, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 ol Lab, Salt LakeCity, UT 84112 USA
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 3, volume: 75, anno: 2001,
pagine: 245 - 252
SICI:
1074-7427(200105)75:3<245:ISIBAA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RATS; HIPPOCAMPUS; DISRUPTS; PREVENTS; MEMORY; MAZE;
Keywords:
hippocampus; learning; memory; contextual fear conditioning; classical conditioning; acetylcholine; muscarinic; acquisition; consolidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Wallenstein, GV Univ Utah, Program Neurosci, Dept Psychol, Cognit Neurobiol Lab, 380 S 1530 E,Room 502, Salt Lake City, UT 84112 USA Univ Utah 380 S 1530 E,Room 502 Salt Lake City UT USA 84112
Citazione:
G.V. Wallenstein e D.R. Vago, "Intrahippocampal scopolamine impairs both acquisition and consolidation ofcontextual fear conditioning", NEUROBIOL L, 75(3), 2001, pp. 245-252

Abstract

Lesions of the dorsal hippocampus have been shown to disrupt both the acquisition and the consolidation of memories associated with contextual fear (fear of the place of conditioning), but do not affect fear conditioning to discrete cues (e.g., a tone). Blockade of central muscarinic cholinergic receptor activation results in selective acquisition deficits of contextual fear conditioning, but reportedly has little effect on consolidation. Here we show for the first time that direct infusion of the muscarinic cholinergic receptor antagonist, scopolamine, into the dorsal hippocampus produces a dose-dependent deficit in both acquisition and consolidation of contextual fear conditioning, while having no impact on simple tone conditioning. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 00:48:52