Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis
Autore:
Miki, T; Liss, B; Minami, K; Shiuchi, T; Saraya, A; Kashima, Y; Horiuchi, M; Ashcroft, F; Minokoshi, Y; Roeper, J; Seino, S;
Indirizzi:
Chiba Univ, Grad Sch Med, Dept Cellular & Mol Med, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 Cellular & Mol Med, Chiba 2608670, Japan Univ Oxford, MRC, Anat Neuropharmacol Unit, Oxford OX1 3TH, England Univ Oxford Oxford England OX1 3TH armacol Unit, Oxford OX1 3TH, England Ehime Univ, Sch Med, Dept Biochem Med, Matsuyama, Ehime 7910295, Japan Ehime Univ Matsuyama Ehime Japan 7910295 Matsuyama, Ehime 7910295, Japan Univ Oxford, Univ Lab Physiol, Oxford OX1 3TH, England Univ Oxford Oxford England OX1 3TH Lab Physiol, Oxford OX1 3TH, England
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 5, volume: 4, anno: 2001,
pagine: 507 - 512
SICI:
1097-6256(200105)4:5<507:AKCITH>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTASSIUM CHANNELS; VENTROMEDIAL HYPOTHALAMUS; SULFONYLUREA RECEPTOR; BODY-WEIGHT; FOOD-INTAKE; GLUCAGON-SECRETION; HORMONE-RELEASE; SKELETAL-MUSCLE; RAT-BRAIN; NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Seino, S Chiba Univ, Grad Sch Med, Dept Cellular & Mol Med, Chiba 2608670,Japan Chiba Univ Chiba Japan 2608670 & Mol Med, Chiba 2608670, Japan
Citazione:
T. Miki et al., "ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis", NAT NEUROSC, 4(5), 2001, pp. 507-512

Abstract

Glucose-responsive (GR) neurons in the hypothalamus are thought to be critical in glucose homeostasis, but it is not known how they function in this context. Kir6.2 is the pore-forming subunit of K-ATP channels in many cell types, including pancreatic beta -cells and heart. Here we show the complete absence of both functional ATP-sensitive K+ (K-ATP) channels and glucose responsiveness in the neurons of the ventromedial hypothalamus (VMH) in Kir6.2(-/-) mice. Although pancreatic alpha -cells were functional in Kir6.2(-/-), the mice exhibited a severe defect in glucagon secretion in response to systemic hypoglycemia. In addition, they showed a complete loss of glucagon secretion, together with reduced food intake in response to neuroglycopenia. Thus, our results demonstrate that K-ATP channels are important in glucose sensing in VMH GR neurons, and are essential for the maintenance of glucose homeostasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:25:40