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Titolo:
A candidate taste receptor gene near a sweet taste locus
Autore:
Montmayeur, JP; Liberles, SD; Matsunami, H; Buck, LB;
Indirizzi:
Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Neurobiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 st, Dept Neurobiol, Boston, MA 02115 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 5, volume: 4, anno: 2001,
pagine: 492 - 498
SICI:
1097-6256(200105)4:5<492:ACTRGN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUTATIVE PHEROMONE RECEPTORS; METABOTROPIC GLUTAMATE-RECEPTOR; CROSS-ADAPTATION; MULTIGENE FAMILY; INBRED STRAINS; MICE; TRANSDUCTION; MOUSE; RESPONSES; SACCHARIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Buck, LB Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Neurobiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Neurobiol, Boston, MA 02115 USA
Citazione:
J.P. Montmayeur et al., "A candidate taste receptor gene near a sweet taste locus", NAT NEUROSC, 4(5), 2001, pp. 492-498

Abstract

The mechanisms underlying sweet taste in mammals have been elusive. Although numerous studies have implicated G proteins in sweet taste detection, the expected G protein-coupled receptors have not been found. Here we describe a candidate taste receptor gene, T1r3, that is located at or near the mouse Sac locus, a genetic locus that controls the detection of certain sweet tastants. T1R3 differs in amino acid sequence in mouse strains with different Sac phenotypes ('tasters' versus 'nontasters'). In addition, a perfect correlation exists between two different T1r3 alleles and Sac phenotypes in recombinant inbred mouse strains. The T1r3 gene is expressed in a subset oftaste cells in circumvallate, foliate and fungiform taste papillae. In circumvallate and foliate papillae, most T1r3-expressing cells also express a gene encoding a related receptor, T1R2 raising the possibility that these cells recognize more than one ligand, or that the two receptors function as heterodimers.

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Documento generato il 03/06/20 alle ore 09:19:20