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Titolo:
Anti-genotoxicity of galangin as a cancer chemopreventive agent candidate
Autore:
Heo, MY; Sohn, SJ; Au, WW;
Indirizzi:
Kangweon Natl Univ, Coll Pharm, Chunchon 200, South Korea Kangweon Natl Univ Chunchon South Korea 200 m, Chunchon 200, South Korea Korea Food & Drug Adm, Div Toxicol, Natl Inst Toxicol Res, Seoul 122704, South Korea Korea Food & Drug Adm Seoul South Korea 122704 Seoul 122704, South Korea Univ Texas, Med Branch, Dept Prevent Med & Community Hlth, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 Community Hlth, Galveston, TX 77555 USA
Titolo Testata:
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
fascicolo: 2, volume: 488, anno: 2001,
pagine: 135 - 150
SICI:
1383-5742(200105)488:2<135:AOGAAC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARYL-HYDROCARBON RECEPTOR; HUMAN-LIVER-MICROSOMES; METHYL-N-NITROSOUREA; PLANT FLAVONOIDS; DIETARY FLAVONOIDS; BREAST-CANCER; ANTIOXIDANT ACTIVITY; LIPID-PEROXIDATION; P-GLYCOPROTEIN; DNA-DAMAGE;
Keywords:
cancer chemopreventive agent; flavonoid; galangin; anti-genotoxicity; enzyme modulation; anti-oxidative activity;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
132
Recensione:
Indirizzi per estratti:
Indirizzo: Heo, MY Kangweon Natl Univ, Coll Pharm, Chunchon 200, South Korea KangweonNatl Univ Chunchon South Korea 200 hon 200, South Korea
Citazione:
M.Y. Heo et al., "Anti-genotoxicity of galangin as a cancer chemopreventive agent candidate", MUT RES-R M, 488(2), 2001, pp. 135-150

Abstract

Flavonoids are polyphenolic compounds that are present in plants. They have been shown to possess a variety of biological activities at non-toxic concentrations in organisms. Galangin, a member of the flavonol class of flavonoid, is present in high concentrations in medicinal plants (e.g. Alpinia officinarum) and propolis, a natural beehive product. Results from in vitro and in vivo studies indicate that galangin with anti-oxidative and free radical scavenging activities is capable of modulating enzyme activities and suppressing the genotoxicity of chemicals. These activities will be discussed in this review. Based on our review, galangin may be a promising candidate for cancer chemoprevention. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 00:49:41