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Titolo:
Synthesis and electrophilic substitution of pyrido[2,3,4-kl]-acridines
Autore:
Koller, A; Rudi, A; Gravalos, MG; Kashman, Y;
Indirizzi:
Tel Aviv Univ, Sch Chem, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 h Chem, IL-69978 Tel Aviv, Israel PharmaMar, Madrid, Spain PharmaMar Madrid SpainPharmaMar, Madrid, Spain
Titolo Testata:
MOLECULES
fascicolo: 4, volume: 6, anno: 2001,
pagine: 300 - 322
SICI:
1420-3049(200104)6:4<300:SAESOP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOMIMETIC SYNTHESIS; AROMATIC ALKALOIDS; DERIVATIVES; PYRIDO<2,3,4-KL>ACRIDINES; 11-HYDROXYASCIDIDEMIN;
Keywords:
pyrido[2,3,4-kl]acridines; biomimetic synthesis; NMR; electrophilic nitration; cytotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Kashman, Y Tel Aviv Univ, Sch Chem, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 69978 Tel Aviv, Israel
Citazione:
A. Koller et al., "Synthesis and electrophilic substitution of pyrido[2,3,4-kl]-acridines", MOLECULES, 6(4), 2001, pp. 300-322

Abstract

Several new pyrido[2,3,4-kl]acridines were synthesized by reacting naphthoquinone, juglone or cyclohexan-1,3-dione with beta,beta ' -diaminoketones in a biomimetic reaction. The: structure of all new compounds :was elucidated by NMR and MS spectroscopy. Electrophilic substitution, mainly nitration,of the various compounds was undertaken and the substitution positions determined. A series of derivatives was prepared and their cytotoxicity towards P-388 mouse lymphoma cells analysed. The most cytotoxic derivatives were found to have: IC50's of 0.05 and 0.1 ug/ml.

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Documento generato il 10/07/20 alle ore 18:59:47