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Titolo:
Ovarian expression of human insulin-like growth factor-I in transgenic mice results in cyst formation
Autore:
Dyck, MK; Parlow, AF; Senechal, JF; Sirard, MA; Pothier, F;
Indirizzi:
Univ Laval, Dept Anim Sci, Ctr Rech Biol Reprod, Quebec City, PQ G1K 7P4, Canada Univ Laval Quebec City PQ Canada G1K 7P4 Quebec City, PQ G1K 7P4, Canada Harbor UCLA Med Ctr, Res & Educ Inst, Natl Hormone & Pituitary Program, Torrance, CA USA Harbor UCLA Med Ctr Torrance CA USA Pituitary Program, Torrance, CA USA
Titolo Testata:
MOLECULAR REPRODUCTION AND DEVELOPMENT
fascicolo: 2, volume: 59, anno: 2001,
pagine: 178 - 185
SICI:
1040-452X(200106)59:2<178:OEOHIG>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; HUMAN CHORIONIC-GONADOTROPIN; MURINE LUTEINIZING-HORMONE; FACTOR SYSTEM COMPONENTS; RAT OVARY; BINDING-PROTEINS; GRANULOSA-CELLS; GENE-EXPRESSION; RECEPTOR GENE; IGF-I;
Keywords:
IGF-I; LH receptor promoter; polycystic ovaries; hyperandrogenism; anovulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Pothier, F Univ Laval, Dept Anim Sci, Ctr Rech Biol Reprod, Pavillon Paul Comtois, Quebec City, PQ G1K 7P4, Canada Univ Laval Pavillon Paul Comtois Quebec City PQ Canada G1K 7P4
Citazione:
M.K. Dyck et al., "Ovarian expression of human insulin-like growth factor-I in transgenic mice results in cyst formation", MOL REPROD, 59(2), 2001, pp. 178-185

Abstract

Insulin-like growth factor-I (IGF-I) has been implicated in a wide varietyof physiological processes including ovarian function. To better understand the ovarian role of IGF-I, transgenic mice harbouring a human IGF-I cD NA(hIGF-I) under the control of the mouse LH receptor promoter were generated. Expression of the hIGF-I, determined by Northern blot, was found to occur in the gonad tissues of these transgenic mice. The hIGF-I protein was also detectable by radioimmunoassay in ovarian extracts as well as in the plasma. The fertility of mating transgenic females, as estimated by the number of implantation sites post-coitum, did not appear to be affected. However, transgenic females who failed to mate and produce offspring were found to possess polycystic ovaries. Evaluation of testosterone, estradiol, and LH levels revealed that transgenic animals had significantly elevated circulating levels of testosterone compared to their non-transgenic littermates, while LH levels in transgenic females were significantly lower. Yet, estradiol appeared to be unaffected. These results support the contention that the IGF system plays an important role in ovarian function and that an imbalance in this system may result in ovarian pathology. Mol. Reprod. Dev. 59:178-185, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:44:58