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Titolo:
alpha-, beta-, gamma-catenin, and p120(CTN) expression during the terminaldifferentiation and fusion of human mononucleate cytotrophoblasts in vitroand in vivo
Autore:
Getsios, S; Chen, GTC; MacCalman, CD;
Indirizzi:
Univ British Columbia, Fac Med, Dept Obstet & Gynaecol, BC Res Inst Childrens & Womens Hlth, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Vancouver BC Canada V5Z 4H4 ver, BC V5Z 4H4, Canada
Titolo Testata:
MOLECULAR REPRODUCTION AND DEVELOPMENT
fascicolo: 2, volume: 59, anno: 2001,
pagine: 168 - 177
SICI:
1040-452X(200106)59:2<168:ABGAPE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN TROPHOBLAST CELLS; E-CADHERIN EXPRESSION; PREIMPLANTATION DEVELOPMENT; JUNCTIONAL COMPLEX; TARGETED MUTATION; ADHESION COMPLEX; EMBRYONIC HEART; PLAKOGLOBIN; PROTEIN; MODULATION;
Keywords:
cadherins; catenins; human placenta; trophoblast differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: MacCalman, CD Univ British Columbia, Fac Med, Dept Obstet & Gynaecol, BC Res Inst Childrens & Womens Hlth, Room I 3091-950,W 28th Ave, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Room I 3091-950,W 28th Ave Vancouver BC Canada V5Z 4H4
Citazione:
S. Getsios et al., "alpha-, beta-, gamma-catenin, and p120(CTN) expression during the terminaldifferentiation and fusion of human mononucleate cytotrophoblasts in vitroand in vivo", MOL REPROD, 59(2), 2001, pp. 168-177

Abstract

The cadherins play key roles in the formation and organization of the mammalian placenta by mediating cellular interactions and the terminal differentiation of trophoblastic cells. Although cadherin function is regulated by the cytoplasmic proteins, known as the catenins, the identity and expression pattern(s) of the catenins present in the trophoblastic cells of the human placenta have not been characterized. In these studies, we have determined that alpha-, beta-, gamma -catenin, and p120(ctn) expression levels are high in villous cytotrophoblasts isolated from the human term placenta but decline as these cells undergo aggregation and fusion to form syncytium withtime in culture. In contrast, the expression levels of these four catenin subtypes remained constant in non-fusing JEG-3 choriocarcinoma cells at allof the time points examined in these studies. alpha-, beta- gamma -catenin, and p120(ctn) expression was further immunolocalized to the mononucleate cells present in these two trophoblastic cell cultures. Similarly, intense immunostaining for all four catenins was detected in the mononucleate villous cytotrophoblasts of the human first trimester placenta. Collectively, these observations demonstrate that the expression levels of alpha-, beta-, gamma -catenin, and p120(ctn) are tightly regulated during the formation of multinucleated syncytium in vitro and in vivo. Mol. Reprod. Dev. 59:168-177, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:17:00