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Titolo:
A novel feature of the multistep phosphorelay in Escherichia coli: a revised model of the RcsC -> YojN -> RcsB signalling pathway implicated in capsular synthesis and swarming behaviour
Autore:
Takeda, S; Fujisawa, Y; Matsubara, M; Aiba, H; Mizuno, T;
Indirizzi:
Nagoya Univ, Sch Agr, Dept Mol Microbiol, Chikusa Ku, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 a Ku, Nagoya, Aichi 4648601, Japan
Titolo Testata:
MOLECULAR MICROBIOLOGY
fascicolo: 2, volume: 40, anno: 2001,
pagine: 440 - 450
SICI:
0950-382X(200104)40:2<440:ANFOTM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSOR-REGULATOR PROTEIN; HIS-ASP PHOSPHORELAY; POLYSACCHARIDE SYNTHESIS; COLANIC ACID; EXOPOLYSACCHARIDE SYNTHESIS; POSITIVE CONTROL; HPT DOMAIN; IN-VITRO; TRANSDUCTION; ARCB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Mizuno, T Nagoya Univ, Sch Agr, Dept Mol Microbiol, Chikusa Ku, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 ya, Aichi 4648601, Japan
Citazione:
S. Takeda et al., "A novel feature of the multistep phosphorelay in Escherichia coli: a revised model of the RcsC -> YojN -> RcsB signalling pathway implicated in capsular synthesis and swarming behaviour", MOL MICROB, 40(2), 2001, pp. 440-450

Abstract

In this study, we re-investigated the previously characterized RcsC (sensor His-kinase) --> RcsB (response regulator) phosphorelay system that is involved in the regulation of capsular polysaccharide synthesis in Escherichiacoil. The previously proposed model hypothesized the occurrence of a direct phosphotransfer from RcsC to RcsB in response to an unknown external stimulus, As judged from the current general view as to the His --> Asp phosphorelay, this RcsC --> RcsB framework is somewhat puzzling, because RcsC appears to contain both a His-kinase domain and a receiver domain, but not a histidine (His)-containing phosphotransmitter domain (e.g. HPt domain). We thus suspected that an as yet unknown mechanism might be underlying in this particular His --> Asp phosphorelay system. Here, we provide several lines of in vivo and in vitro evidence that a novel and unique His-containing phosphotransmitter (named YojN) is essential for this signalling system. A revised model is proposed in which the multistep RcsC --> YojN --> RcsB phosphorelay is implicated. It was also demonstrated that this complex signalling system is somehow involved in the modulation of a characteristic behaviour of E. coli cells during colony formation on the surface of agar plates, namely swarming.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:47:13