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Titolo:
Cell surface glypicans are low-affinity endostatin receptors
Autore:
Karumanchi, SA; Jha, V; Ramchandran, R; Karihaloo, A; Tsiokas, L; Chan, BD; Dhanabal, M; Hanai, J; Venkataraman, G; Shriver, Z; Keiser, N; Kalluri, R; Zeng, HY; Mukhopadhyay, D; Chen, RL; Lander, AD; Hagihara, K; Yamaguchi, Y; Sasisekharan, R; Cantley, L; Sukhatme, VP;
Indirizzi:
Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 d, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr, Ctr Canc, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 c, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 l, Boston, MA 02215 USA Harvard Univ, Sch Med, Boston, MA 02215 USA Harvard Univ Boston MA USA 02215 vard Univ, Sch Med, Boston, MA 02215 USA MIT, Div Bioengn & Environm Hlth, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 oengn & Environm Hlth, Cambridge, MA 02139 USA Burnham Inst, La Jolla, CA 92037 USA Burnham Inst La Jolla CA USA 92037Burnham Inst, La Jolla, CA 92037 USA Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 v & Cell Biol, Irvine, CA 92697 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 4, volume: 7, anno: 2001,
pagine: 811 - 822
SICI:
1097-2765(200104)7:4<811:CSGALE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPARAN-SULFATE PROTEOGLYCAN; ANGIOGENESIS INHIBITOR ENDOSTATIN; BASEMENT-MEMBRANE; GROWTH-FACTOR; TUMOR-GROWTH; ENDOGENOUS INHIBITOR; SIGNAL-TRANSDUCTION; COLLAGEN-XVIII; BINDING; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Sukhatme, VP Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USABeth Israel Deaconess Med Ctr Boston MA USA 02215 02215 USA
Citazione:
S.A. Karumanchi et al., "Cell surface glypicans are low-affinity endostatin receptors", MOL CELL, 7(4), 2001, pp. 811-822

Abstract

Endostatin, a collagen XVIII fragment, is a potent antiangiogenic protein. We sought to identify its endothelial cell surface receptor(s). Alkaline phosphatase-tagged endostatin bound endothelial cells revealing two binding affinities. Expression cloning identified glypican, a cell surface proteoglycan as the lower-affinity receptor. Biochemical and genetic studies indicated that glypicans' heparan sulfate glycosaminoglycans were critical for endostatin binding. Furthermore, endostatin selected a specific octasulfated hexasaccharide from a sequence in heparin. We have also demonstrated a rolefor endostatin in renal tubular cell branching morphogenesis and show thatglypicans serve as low-affinity receptors for endostatin in these cells, as in endothelial cells. Finally, antisense experiments suggest the criticalimportance of glypicans in mediating endostatin activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 14:40:20